Research Techniques in Medicinal Chemistry (Foundations in Drug Discovery)

(30:715:451 or 16:663:501)

Course Instructor

Times and Location

T, TH:  3:40 – 5:00 PM,  PH 130

Fall 2023 Exam Schedule

Exam # 1 –  TBD

Exam # 2 –  TBD

Final Exam – TBD

Course Description:   This is an intensive course composed of medicinal and physical organic chemistry principles and techniques and will provide a basis for students to enter and succeed in a medicinal chemistry laboratory setting.  The course will cover physical organic principles, reaction mechanisms, and their interrelation with medicinal chemistry and enzymology.  The organic chemical principles will cover the conceptual aspects of orbitals and bonding, stereochemistry, conformational analysis, acid/base theory, and substituent effects.  Concepts surrounding elimination reactions, nucleophilic and electrophilic substitution using stereoelectronic and orbital theory, and general reaction mechanisms will be explored.  Lastly, the course will cover techniques needed in a medicinal chemistry laboratory including assay development and interpretation, as well as synthetic organic techniques and strategies.  This course is designed as an introductory graduate course or an advanced undergraduate course for students who have completed two semesters of organic chemistry with an associated laboratory component.




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Research Techniques in Medicinal Chemistry