Principles of Drug Design
16:663:502 for graduate students / 30:715:452 for pharmacy students

Faculty

  • Dr. Longqin Hu (Course coordinator)
    “Drug Discovery, Lead Optimization Approaches, Enzymes, Receptors, Prodrug Design, and Combinatorial Chemistry”
  • Dr. Vlad Kholodovych (Rutgers Office of Advanced Research Computing)
    “Computer Aided Drug Design (CADD)”
  • Dr. Youyi Peng (Rutgers Cancer Institute of New Jersey)
    “Computer Aided Drug Design (CADD)”

 

Invited Seminar Speakers

  • Dr. Nick Meanwell (Bristol-Myers Squibb): “Applications of Bioisosteres in Drug Design” – Monday, January 27, 2020 and “Applications of Fluorines in Drug Design” – Wednesday, February 26, 2020
  • Dr. Zhoupeng Zhang (Merck): “Metabolic ID and Profiling in Drug Design” – Monday, March 2, 2020
  • Dr. Sam Chackalamannil (Rutgers Med Chem): “Discovery of Vorapaxar – A New Antiplatelet Agent” – Wednesday, March 4, 2020
  • Dr. Mark R. Player (Jannsen): “Discovery and safety de-risking of a GPR40 full agonist for the treatment of type 2 diabetes” – Monday, March 9, 2020
  • Dr. Ashwinikumar Gavai (Bristol-Myers Squibb): “Discovery of an oral BET inhibitor for the treatment of cancer” – Wednesday, March 11, 2020
  • Dr. Ed LaVoie (Rutgers Med Chem): “Design and Discovery of FtsZ-Targeting Compounds as Novel Antibiotics” – Wednesday, April 22, 2020
  • Dr. Lou Lombardo (Bristol-Myers Squibb): “Sprycel and Tyk2 pseudokinase stories” – Monday, April 27, 2020
  • Dr. Ray Bakhtiar (Teva Pharmaceuticals): “Monoclonal, antibody drug conjugates & peptide therapeutics” – Wednesday, April 29, 2020 

 

Times and Location

Mondays and Wednesdays:  6:15 – 7:35 PM, PH 288

Examinations

  • Exam 1 – Monday March 23, 2020 – 6:15pm – 7:35pm Room 288
  • Exam 2 – Monday May 4, 2020 – 6:15pm – 7:35pm Room 288

 

Grading

 – A term paper, computational project(s), and two exams

Term paper on a drug target with 5 drug design principles20%
Exam on approaches to drug discovery (analog design), enzymes, receptors, prodrugs, and combinatorial chemistry40%
Computational project(s)35%
Class/seminar attendance and participation5%
Total100%

 

Useful Links

  • Literature Search Links
  • Alphabetical List of Chemistry Journals – A list of almost 700 links to chemistry magazines and journals
  • Alphabetical List of Journal Abbreviations
  • Drug discovery & development Glossary
  • Glossary of terms used in medicinal chemistry- IUPAC -Pure Appl. Chem., 70, 1129-1143 (1998)
  • Glossary of terms used in combinatorial chemistry (pdf file) – J.Comb.Chem.2000,2,562-578 or PureAppl.Chem.1999,71(12),2349-2365.
  • Modern Drug Discovery
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