Principles of Drug Design
16:663:502 for graduate students / 30:715:452 for pharmacy students

Faculty

  • Dr. Longqin Hu (Course coordinator)
    “Drug Discovery, Lead Optimization Approaches, Enzymes, Receptors, Prodrug Design, and Combinatorial Chemistry”
  • Dr. Vlad Kholodovych (Rutgers Office of Advanced Research Computing)
    “Computer Aided Drug Design (CADD)”
  • Dr. Youyi Peng (Rutgers Cancer Institute of New Jersey)
    “Computer Aided Drug Design (CADD)”

 

Invited Seminar Speakers

  • Applications of Bioisosteres in Drug Design 
    • Dr. Nick Meanwell (Bristol-Myers Squibb)
    • 5:40pm – 7:00pm, PH 288 – Tuesday, January 25, 2022
  • Applications of Fluorines in Drug Design 
    • Dr. Nick Meanwell (Bristol-Myers Squibb)
    • 5:40pm – 7:00pm, PH 288 – Tuesday, February 22, 2022
  • Metabolic ID and Profiling in Drug Design 
    • Dr. Zhoupeng Zhang (Merck Research Laboratory)
    • 5:40pm – 7:00pm, PH 288 – Thursday, February 24, 2022
  • Discovery of Vorapaxar – A New Antiplatelet Agent 
    • Dr. Sam Chackalamannil (Rutgers Med Chem, formerly Merck)
    • 5:40pm – 7:00pm, PH 288 – Tuesday, March 1, 2022
  • Design and Discovery of FtsZ-Targeting Compounds as Novel Antibiotics 
    • Dr. Ed LaVoie (Rutgers Med Chem)
    • 5:40pm – 7:00pm, PH 288 – Thursday, March 3, 2022
  • Innovative Chemistry Capabilities in Current Drug Discovery Paradigm 
    • Dr. Zhicai Shi (Janssen Pharmaceuticals, Johnson & Johnson)
    • 5:40pm – 7:00pm, PH 288 – Tuesday, March 8, 2022
  • Discovery of an NLRP3 Agonist as an Immune-Oncology Agent
    • Dr. Ashvinkumar Gavai (Bristol-Myers Squibb)
    • 5:40pm – 7:00pm, PH 288 – Tuesday, April 19, 2022
  • Discovery of MK-0616, a Novel Orally Active Tricyclic Peptide PCSK9 Inhibitor to Lower LDL Cholesterol 
    • Dr. Blair Wood (Merck Research Laboratory)
    • 5:40pm – 7:00pm, PH 288 – Thursday, April 21, 2022
  • Monoclonal, Antibody Drug Conjugates & Peptide Therapeutics
    • Dr. Ray Bakhtiar (Organon & Co)
    • 5:40pm – 7:00pm, PH 288 – Tuesday, April 26, 2022
  • Discovery of Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interactions 
    • Dr. Longqin Hu (Rutgers Med Chem)
    • 5:40pm – 7:00pm, PH 288 – Thursday, April 28, 2022

 

Times and Location

  • Tuesdays and Thursdays:  5:40 – 7:00 PM, PH 288

Examinations

  • A term paper or minireview, computational project(s) and one exam

Grading

Term paper on a drug target with 5 drug design principles or a minireview article to be published in Med.Chem.Res.20%
Exam on approaches to drug discovery (analog design), enzymes, receptors, prodrugs, and combinatorial chemistry40%
Computational project(s)35%
Class/seminar attendance and participation5%
Total100%

 

Useful Links

  • Literature Search Links
  • Alphabetical List of Chemistry Journals – A list of almost 700 links to chemistry magazines and journals
  • Alphabetical List of Journal Abbreviations
  • Drug discovery & development Glossary
  • Glossary of terms used in medicinal chemistry- IUPAC -Pure Appl. Chem., 70, 1129-1143 (1998)
  • Glossary of terms used in combinatorial chemistry (pdf file) – J.Comb.Chem.2000,2,562-578 or PureAppl.Chem.1999,71(12),2349-2365.
  • Modern Drug Discovery
  •