Phoebe Stapleton, PhD, ATC

Associate Professor

Pharmacology and Toxicology

Education & Training

PhD - West Virginia University
MSEd - Southern Illinois University at Edwardsville, IL
BS - State University of New York College at Cortland, NY
Post-Doctoral Fellowship - West Virginia University

Certifications

Certified Athletic Trainer

Research Interests

The microcirculation branch of the cardiovascular system encompasses the arterioles, capillaries, and venules within an organ or tissue of interest. These highly active vessels serve to maintain homeostasis by regulating blood flow and tissue perfusion, thus providing nutrients and removing waste. Central to proper reactivity is the health and function of the endothelium, a single cell layer lining the vasculature. The Stapleton laboratory investigates the microvascular perturbations associated with normal physiological challenges (exercise or pregnancy), disease, and exposures to environmental and/or occupational xenobiotics.
Using engineered nanomaterials, studies focus on the question: how can something we inhale affect the cardiovascular system? Recently, her research group has investigated non-traditional models of exposure by incorporating reproductive toxicology. These studies focus on exposures during pregnancy leading to the development of a hostile gestational environment identified through microvascular evaluations of the mother. These prenatal exposures impact fetal development and may predispose future generations to cardiovascular aberrations.

Publications

Awards

2016 - Invited Speaker at the NIEHS 50th Anniversary Celebration, SOT and NIEHS Past, Present, and Future: 50 Years of Collaboration, National Institute of Environmental Health Sciences, Research Triangle Park, NC: “Toxicology for the next generation”
2016 - Past-President, Alleghany-Erie Regional Chapter of the Society of Toxicology
2016 - Impact Award, Cardiovascular Specialty Section, Society of Toxicology
2016 - Best Publication Award, Nanotoxicology Specialty Section, Society of Toxicology
2015-2020 - Pathway to Independence Award, K99/R00, NIEHS
2015 - Invited Speaker at the 10th World Congress for Microcirculation, Microvascular plasticity and developmental priming: impact on human health Symposium, Kyoto, Japan: “Gestational xenobiotic exposures: microvascular implications for the past, present, and future.”
2015 - President, Alleghany-Erie Regional Chapter of the Society of Toxicology
2015 - Federation of American Societies for Experimental Biology (FASEB), Boston, MA. American Society for Pharmacology and Experimental Therapeutics (ASPET) Symposium – Nanotoxicology: Small particles, big concerns: “Vascular consequences of nanomaterial exposure: From the heart to the fetus”
2014 - Young Investigator Travel Award to attend NIH Conference Small Blood Vessels: Big Health Problems?, The Microcirculation Society
2014 - President-Elect, Alleghany-Erie Regional Chapter of the Society of Toxicology
2014 - Best Postdoctoral Publication Award, Postdoctoral Assembly, Society of Toxicology
2014 - Outstanding Postdoctoral Fellow, Nanotoxicology Specialty Section, Society of Toxicology
2013 - Alleghany-Erie Society of Toxicology Postdoctoral Travel Award
2013 - Postdoctoral Achievement Award, Women in Toxicology SIG, Society of Toxicology
2013-2015 - National Research Service Award (NRSA), F32, NIEHS
2013 - EJ Van Liere Featured Postdoctoral Fellow, West Virginia University
2012 - Review Editor, Frontiers in Vascular Physiology
2012 - DMT Postdoctoral Travel Award, Cardiovascular Toxicology Specialty Section, Society of Toxicology