Principles of Drug Design
16:663:502 for graduate students / 30:715:452 for pharmacy students
Faculty
- Dr. Longqin Hu (Course coordinator)
“Drug Discovery, Lead Optimization Approaches, Enzymes, Receptors, Prodrug Design, and Combinatorial Chemistry” - Dr. Vlad Kholodovych (Rutgers Office of Advanced Research Computing)
“Computer Aided Drug Design (CADD)” - Dr. Youyi Peng (Rutgers Cancer Institute of New Jersey)
“Computer Aided Drug Design (CADD)”
Invited Seminar Speakers
- Applications of Bioisosteres in Drug Design
- Dr. Nick Meanwell (Bristol-Myers Squibb)
- 5:40pm – 7:00pm, PH 288 – Tuesday, January 25, 2022
- Applications of Fluorines in Drug Design
- Dr. Nick Meanwell (Bristol-Myers Squibb)
- 5:40pm – 7:00pm, PH 288 – Tuesday, February 22, 2022
- Metabolic ID and Profiling in Drug Design
- Dr. Zhoupeng Zhang (Merck Research Laboratory)
- 5:40pm – 7:00pm, PH 288 – Thursday, February 24, 2022
- Discovery of Vorapaxar – A New Antiplatelet Agent
- Dr. Sam Chackalamannil (Rutgers Med Chem, formerly Merck)
- 5:40pm – 7:00pm, PH 288 – Tuesday, March 1, 2022
- Design and Discovery of FtsZ-Targeting Compounds as Novel Antibiotics
- Dr. Ed LaVoie (Rutgers Med Chem)
- 5:40pm – 7:00pm, PH 288 – Thursday, March 3, 2022
- Innovative Chemistry Capabilities in Current Drug Discovery Paradigm
- Dr. Zhicai Shi (Janssen Pharmaceuticals, Johnson & Johnson)
- 5:40pm – 7:00pm, PH 288 – Tuesday, March 8, 2022
- Discovery of an NLRP3 Agonist as an Immune-Oncology Agent
- Dr. Ashvinkumar Gavai (Bristol-Myers Squibb)
- 5:40pm – 7:00pm, PH 288 – Tuesday, April 19, 2022
- Discovery of MK-0616, a Novel Orally Active Tricyclic Peptide PCSK9 Inhibitor to Lower LDL Cholesterol
- Dr. Blair Wood (Merck Research Laboratory)
- 5:40pm – 7:00pm, PH 288 – Thursday, April 21, 2022
- Monoclonal, Antibody Drug Conjugates & Peptide Therapeutics
- Dr. Ray Bakhtiar (Organon & Co)
- 5:40pm – 7:00pm, PH 288 – Tuesday, April 26, 2022
- Discovery of Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interactions
- Dr. Longqin Hu (Rutgers Med Chem)
- 5:40pm – 7:00pm, PH 288 – Thursday, April 28, 2022
Times and Location
- Tuesdays and Thursdays: 5:40 – 7:00 PM, PH 288
Examinations
- A term paper or minireview, computational project(s) and one exam
Grading
| Term paper on a drug target with 5 drug design principles or a minireview article to be published in Med.Chem.Res. | 20% |
| Exam on approaches to drug discovery (analog design), enzymes, receptors, prodrugs, and combinatorial chemistry | 40% |
| Computational project(s) | 35% |
| Class/seminar attendance and participation | 5% |
| Total | 100% |
Useful Links
- Literature Search Links
- Alphabetical List of Chemistry Journals – A list of almost 700 links to chemistry magazines and journals
- Alphabetical List of Journal Abbreviations
- Drug discovery & development Glossary
- Glossary of terms used in medicinal chemistry- IUPAC -Pure Appl. Chem., 70, 1129-1143 (1998)
- Glossary of terms used in combinatorial chemistry (pdf file) – J.Comb.Chem.2000,2,562-578 or PureAppl.Chem.1999,71(12),2349-2365.
- Modern Drug Discovery
