Graduate Program Curriculum

PhD in Medicinal Chemistry

The Ernest Mario School of Pharmacy has established a joint PharmD/PhD program to meet the needs of interests of highly motivated PharmD students. The program enables students to complete both degrees in approximately nine years by beginning their PhD coursework and research while still enrolled in the PharmD program.

Required Core Courses for Ph.D. (17 credits)

  • Foundations in Drug Discovery (16:663:501) (3 credits, offered once every two years) – Fall
  • Principles of Drug Design (16:663:502) (3 credits, offered once every two years) – Spring
  • Interpretation of Organic Spectra (3 credits) (16:160:515) – Spring
  • Modern Synthetic Organic Chemistry (3 credits) (16:160:503) – Spring
  • Independent Research Proposal (3 credits) (16:663:540)
  • Seminar in Medicinal Chemistry, two (2 credits) (16:663:601 or 602)

Electives: 6 Credits from the approved list or courses approved by the advisor.

Lab Rotation (3 credits) (16.663.508)

Research in Medicinal Chemistry (16:663:701,702) (46 research credits).

Qualifying Exam: A qualifying exam is required for PhD candidacy. In the fall semester of the first year, students must decide on the members on their thesis committee and coordinate with medicinal chemistry program members to arrange for the qualifying exam. The deadline for the qualifying exam is August of the second year. For a qualifying exam, students will give a presentation on their thesis project, which should include background, goals, and any preliminary results if available.

  • Students admitted in odd years:

    Semester/Year Course Credits Total
    Year 1 Fall ·        Med Chem Research Principles

    ·        Molecular Biology and Biochemistry

    ·        Elective 1 (suggested: Advanced Organic)

    ·        Rotations (required for Ph.D.)

    12 12
    Year 1 Spring ·        Modern Synthetic Organic Chemistry

    ·        Interpretation of Organic Spectra

    ·        Principles of Drug Design

    9 21
    Year 2 Fall ·        Elective 2 (can take in Spring if necessary) 3 24
    Year 2 Spring ·        Qualifying Exam 24
    Year 3 Spring ·        Seminar 1 1 25
    Year 4 ·        Independent Research Proposal 3 28
    Year 5 ·        Seminar 2

    ·        Thesis

    1 29

    Students admitted in even years:

    Semester/Year Course Credits Total
    Year 1 Fall ·        Molecular Biology and Biochemistry

    ·        Elective 1 (suggested: Advanced Organic)

    ·        Elective 2 (can take in Spring Year 1 if necessary)

    ·        Rotations (required for Ph.D. )

    12 12
    Year 1 Spring ·        Modern Synthetic Organic Chemistry

    ·        Interpretation of Organic Spectra

    6 18
    Year 2 Fall ·        Med Chem Research Principles 3 21
    Year 2 Spring ·        Principles of Drug Design

    ·        Qualifying Exam

    3 24
    Year 3 Spring ·        Seminar 1 1 25
    Year 4 ·        Independent Research Proposal 3 28
    Year 5 ·        Seminar 2

    ·        Thesis

    1 29
  • A qualifying exam is required for PhD candidacy. In the fall semester of the first year, students must decide on the members on their thesis committee and coordinate with medicinal chemistry program members to arrange for the qualifying exam. The deadline for the qualifying exam is August of the second year, however PharmD/PhD students are encouraged to qualify by the end of their first year. For a qualifying exam, students will give a presentation on their thesis project, which should include background, goals, and any preliminary results if available. Preliminary results are useful, however, not required. All didactic course work must be complete in order to pass your qualifying exam (excludes Independent Research Proposal and Seminar in Medicinal Chemistry). Overall, the committee will evaluate five areas:

    1. The student’s ability to understand in a broad context their area of research.
    2. Their ability to plan and execute rationally designed experiments.
    3. Their effort (not results) in the laboratory up until this point.
    4. Their proposal for future work on their project.
    5. Their performance in coursework.

    Students are expected to deliver a one-hour presentation covering the background, experiment design, research output, conclusion, and perspectives. Committee members will raise questions during or after the presentation. Students will receive pass, fail, or conditional pass upon voting from the dissertation committee members. Students who fail the qualifying exam will be advised to graduate with a master’s degree. If you are successful with the qualifying exam, your committee members will then sign paperwork which you will need to submit to the School of Graduate Studies, and you will be formally admitted into candidacy for a Ph.D. degree. In the event of a conditional pass your committee will provide you with a set of requirements that you must meet to pass your qualifying exam. You will then have four to six months to reattempt your qualifying exam in which the only outcomes are pass or fail. Students who fail in the second attempt will be dismissed from the graduate program and be advised to graduate with a MSc degree should he/she meets the requirements of MSc degree.

  • The Independent Research Proposal is a course taken in the fourth year of candidacy.  Students write a R21 style proposal proposing a project that is distinct from their dissertation work.  The proposal should consist of a single page specific aims page and a six-page research proposal. When complete (your advisor cannot edit it for you), schedule a meeting of the dissertation committee and submit copies of the written document to each member (allow at least two weeks for them to read the proposal). At the scheduled meeting, you will present your proposal to the committee (PowerPoint). Members of the committee may ask questions about anything in the proposal.

PharmD-PhD in Medicinal Chemistry

The Ernest Mario School of Pharmacy has established a joint PharmD/PhD program to meet the needs of interests of highly motivated PharmD students. The program enables students to complete both degrees in approximately nine years by beginning their PhD coursework and research while still enrolled in the PharmD program.

Required Core Courses for Ph.D. (17 credits)

  • Foundations in Drug Discovery (16:663:501) (3 credits, offered once every two years) – Fall
  • Principles of Drug Design (16:663:502) (3 credits, offered once every two years) – Spring
  • Interpretation of Organic Spectra (3 credits) (16:160:515) – Spring
  • Modern Synthetic Organic Chemistry (3 credits) (16:160:503) – Spring
  • Independent Research Proposal (3 credits) (16:663:540)
  • Seminar in Medicinal Chemistry, two (2 credits) (16:663:601 or 602)

Electives: 6 Credits from the approved list or courses approved by the advisor.

Lab Rotation (3 credits) (16.663.508)

Research in Medicinal Chemistry (16:663:701,702) (46 research credits).

Qualifying Exam: A qualifying exam is required for PhD candidacy. In the fall semester of the first year, students must decide on the members on their thesis committee and coordinate with medicinal chemistry program members to arrange for the qualifying exam. The deadline for the qualifying exam is August of the second year. For a qualifying exam, students will give a presentation on their thesis project, which should include background, goals, and any preliminary results if available.

  • Semester/Year Course Credits Total
    P1-P2 ·        Med Chem Research Principles (Spring)

    ·        Principles of Drug Design (Spring)

    ·        Rotations

    9 9
    P3-P4 ·        Modern Synthetic Organic Chemistry (Spring)

    ·        Elective 1 (suggested: Advanced Organic, Fall)

    ·        Interpretation of Organic Spectra (Spring)

    9 18
    Year 1 Fall ·        Elective 2 3 21
    Year 1 Spring ·        Qualifying Exam 0 21
    Year 2 Fall 0 21
    Year 2 Spring ·        Seminar 1 1 22
    Year 3 Spring ·        Independent Research Proposal 3 25
    Year 4 ·        Seminar 2

    ·        Thesis

    1 26

     

  • A qualifying exam is required for PhD candidacy. In the fall semester of the first year, students must decide on the members on their thesis committee and coordinate with medicinal chemistry program members to arrange for the qualifying exam. The deadline for the qualifying exam is August of the second year, however PharmD/PhD students are encouraged to qualify by the end of their first year. For a qualifying exam, students will give a presentation on their thesis project, which should include background, goals, and any preliminary results if available. Preliminary results are useful, however, not required. All didactic course work must be complete in order to pass your qualifying exam (excludes Independent Research Proposal and Seminar in Medicinal Chemistry). Overall, the committee will evaluate five areas:

    1. The student’s ability to understand in a broad context their area of research.
    2. Their ability to plan and execute rationally designed experiments.
    3. Their effort (not results) in the laboratory up until this point.
    4. Their proposal for future work on their project.
    5. Their performance in coursework.

    Students are expected to deliver a one-hour presentation covering the background, experiment design, research output, conclusion, and perspectives. Committee members will raise questions during or after the presentation. Students will receive pass, fail, or conditional pass upon voting from the dissertation committee members. Students who fail the qualifying exam will be advised to graduate with a master’s degree. If you are successful with the qualifying exam, your committee members will then sign paperwork which you will need to submit to the School of Graduate Studies, and you will be formally admitted into candidacy for a Ph.D. degree. In the event of a conditional pass your committee will provide you with a set of requirements that you must meet to pass your qualifying exam. You will then have four to six months to reattempt your qualifying exam in which the only outcomes are pass or fail. Students who fail in the second attempt will be dismissed from the graduate program and be advised to graduate with a MSc degree should he/she meets the requirements of MSc degree.

  • The Independent Research Proposal is a course taken in the third or forth year of candidacy.  Students write a R21 style proposal proposing a project that is distinct from their dissertation work.  The proposal should consist of a single page specific aims page and a six-page research proposal. When complete (your advisor cannot edit it for you), schedule a meeting of the dissertation committee and submit copies of the written document to each member (allow at least two weeks for them to read the proposal). At the scheduled meeting, you will present your proposal to the committee (PowerPoint). Members of the committee may ask questions about anything in the proposal.

MS in Medicinal Chemistry

Required Core Courses (16 credits):

  • Medicinal Chemistry: Research Techniques and Principles (16:663:501) – Fall
  • Principles of Drug Design (16:663:502) – Spring
  • Molecular Biology and Biochemistry (3 credits) (16:115:511) – Fall
  • Interpretation of Organic Spectra (16:160:515) – Spring
  • Modern Synthetic Organic Chemistry (16:160:503) – Spring (as of 2024-25)
  • Seminar in Medicinal Chemistry (16:663:601 or 602)

Thesis option:

  • Electives (3 credits)
  • Lab Rotation (3 credits) (16.663.508)
  • Research in Medicinal Chemistry (16:663:701,702) (9 research credits)

Non-Thesis option:

  • Electives (12 credits)
  • Non-Thesis Masters Programmatic Study in Medicinal Chemistry (16:663:620) (3 credits)
  • Students admitted in odd years:

    Semester/Year Course Credits Total
    Year 1 Fall ·        Med Chem Research Principles

    ·        Elective 1 and/or Molecular Biology and Biochemistry

    ·        Rotations

    9 9
    Year 1 Spring ·        Modern Synthetic Organic Chemistry

    ·        Interpretation of Organic Spectra

    ·        Principles of Drug Design

    ·        Thesis research project

    9 18
    Year 2 Fall ·        Elective 1 and/or Molecular Biology and Biochemistry

    ·        Seminar 2

    ·        Thesis research project

    4 22
    Year 2 Spring ·        Thesis research project 22
    Year 3 Fall ·        Dissertation and thesis defense 22

    Students admitted in even years:

    Semester/Year Course Credits Total
    Year 1 Fall ·        Molecular Biology and Biochemistry

    ·        Elective 1

    ·        Rotations

    9 9
    Year 1 Spring ·        Modern Synthetic Organic Chemistry

    ·        Interpretation of Organic Spectra

    ·        Thesis research project

    9 18
    Year 2 Fall ·        Med Chem Research Principles

    ·        Seminar 2

    ·        Thesis research project

    4 22
    Year 2 Spring ·        Principles of Drug Design

    ·        Thesis research project

    22
    Year 3 Fall ·        Dissertation and thesis defense 22

     

  • Students admitted in odd years:

    Semester/Year Course Credits Total
    Year 1 Fall ·        Med Chem Research Principles

    ·        Elective 1 (suggested Adv Organic)

    ·        Elective 2

    9 9
    Year 1 Spring ·        Modern Synthetic Organic Chemistry

    ·        Interpretation of Organic Spectra

    ·        Principles of Drug Design

    9 18
    Year 2 Fall ·        Molecular Biology and Biochemistry

    ·        Seminar 1

    ·        Elective 3

    7 25
    Year 2 Spring ·        Elective 4

    ·        Non-Thesis Masters Programmatic Study in Medicinal Chemistry

    6 31

    Students admitted in even years:

    Semester/Year Course Credits Total
    Year 1 Fall ·        Molecular Biology and Biochemistry

    ·        Elective 1  (suggested Adv Organic)

    ·        Elective 2

    9 9
    Year 1 Spring ·        Modern Synthetic Organic Chemistry

    ·        Interpretation of Organic Spectra

    ·        Elective 3

    9 18
    Year 2 Fall ·        Med Chem Research Principles

    ·        Seminar 1

    ·        Elective 4

    7 25
    Year 2 Spring ·        Principles of Drug Design

    ·        Non-Thesis Masters Programmatic Study in Medicinal Chemistry

    6 31
  • All non-thesis MS students in the Graduate Program in Medicinal Chemistry are required to take the Non-Thesis Masters Programmatic Study in Medicinal Chemistry (16:663:620) before they can graduate. This is a literature review or a small research project culminating with a final critical essay that a non-thesis student needs to write and present to a master’s committee of three members. Students can perform a variety of projects under the non-thesis option. Examples of a suitable project for the non-thesis programmatic study include:

    • Surveying the literature on a new drug target or a class of drugs and writing a critical, focused paper on the topic.
    • Performing a small research project that is not as involved as a thesis and writing a project report describing their study and significant results obtained. The research projects can be on a variety of topics such as:
      • Development and application of a new analytical method using LCMS,
      • Identification of new drug metabolites using LCMS and/or NMR,
      • Optimization of a new set of reaction conditions for a chemical
        conversion,
      • A computational docking and virtual screening project

    The non-thesis option is for students who are working and cannot commit to the time necessary for a thesis or who don’t wish to perform a large scale project like a thesis. NOTE: ALL students must have a faculty advisor for their project. Students are not assigned to a faculty member; but, instead they must take the initiative to contact a faculty member working in their area of interest. The sooner a student finds an advisor the better!  Students need to develop with their advisor an appropriate topic for the critical essay. A term paper submitted for another course is unacceptable as a critical essay, and the submission of such will be considered as a violation of academic integrity.