Lab Affiliation

LCR 217, Ernest Mario School of Pharmacy

Education & Training

PhD – University of California at Berkeley, CA
BS – Nanjing Normal University, China
Post-Doctoral Fellowship – NCI-Frederick Cancer R and D Center, Frederick, MD

Research Interests

The goal of our research is to understand what and how biological signals regulate normal and pathological processes in the nervous system. Recently, my laboratory has been investigating the molecular mechanisms by which ephrin family cell surface proteins regulate embryonic development. Our studies in the past 20 years have shown that ephrins play key roles in many biological processes including lens development and axon guidance during neural development. Loss of ephrin-A5 activity leads to defects in regulations of animal male aggression and maternal care. Our recent effort has been directed towards understanding molecular signals that may regulate ALS pathogenesis and motor neuron survival using a systems biology approach.

Publications

Awards

2014 – William M. and Myrle W. Garbe Professor of Cancer and Leukemia Research
1994, 2001, 2002, 2003 – Johnson and Johnson Discovery Award
1991 – Award for Postdoctoral Support, Robert and Claire Pasarow Foundation
1983-1988 Training Grant for Molecular Biology, National Institutes of Health
1983 – First Place, Graduate Entrance Test for Graduate School of Institute of Genetics, China