Andrew Gow, PhD

Professor

Pharmacology and Toxicology

Lab Affiliation: Gow Lab

Education & Training

PhD - Exercise Physiology - Temple University, Philadelphia, PA
MEd - Exercise Science - Temple University, Philadelphia, PA
BSc - Biochemistry - University of Edinburgh, Edinburgh, Scotland, UK
Post-Doctoral Fellowship - Oxidative Stress - University of Pennsylvania, PA

Research Interests

Overall my research focuses on how redox active molecules play a role in cellular signaling. In particular, I am interested in how nitric oxide (NO) operates in both health and disease. Recently, I have been investigating how NO modifies other biomolecules, such as the pulmonary collectin SP-D, to generate novel signals. The lung represents an ideal organ system to work in for these experiments as all three isoforms of NO Synthase (NOS) are expressed there, and NOS2 is critically important in regulating the cycle of inflammation and repair that occurs following lung injury. These studies are integrative projects requiring the use of techniques ranging from protein chemistry to organ-level physiology and involving an extensive understanding of NO and its chemistry as well as the cell biology of inflammation. I have conducted a range of studies examining NO, pulmonary collectins, and inflammatory lung disease, using both animal models and human samples. Recently I have investigated the role of NO in a rare metastatic lung disease, Lymphangioleiomyomatosis. In the conduct of my research, I have administered projects funded by the NIH and other agencies, coordinated with collaborators, and produced several peer-reviewed publications. The development of strong collaborative relationships is necessary in modern biomedical science and in this regard I have been successful both within and outside of my own institution.

Publications