Grace L. Guo, MBBS, PhD
ASPET is pleased to award Dr. Grace L. Guo, MBBS, PhD from Rutgers University the 2024 Division for Toxicology Career Award. The ASPET Division for Toxicology established this award to recognize outstanding original research contributions to toxicology by an established investigator.
Dr. Guo is receiving this award in recognition of her innovative research and development of new technologies that have led to the discovery of fundamental and transformative concepts regarding the effects of intestine-liver crosstalk on liver metabolism and pathogenesis and an understanding of the underlying molecular mechanisms following disruption of homeostasis of bile acids and exposure to xenobiotic chemicals.
Dr. Guo has dedicated her research career on the molecular mechanisms of regulation of drug metabolism, bile acid signaling and toxicology by nuclear receptors, including FXR, PXR and CAR. She made an important discovery in determining the molecular mechanisms by which xenobiotic nuclear receptors regulate chemical disposition. She is one of the pioneer scientists discovering the importance of intestinal FXR and bile acid signaling in regulating liver functions and disease. Her lab has made several genetically modified mouse models to advance the understanding of human physiology, pathology, pharmacology and toxicology. She has been funded by the NIH and the VA for the last 20 years, published over 140 peer-reviewed papers in pharmacology, toxicology and hepatology journals, mentored many students and fellows, and served on the NIH and VA study sections. Dr. Guo has been actively involved in professional societies to advance the field of toxicology, drug metabolism, and hepatology. This Toxicology Career Award recognizes her research achievement, training of graduate students, and dedicated services to professional societies and research community. Dr. Guo has been a member of ASPET since 2008
The award will be presented by the Division for Toxicology on Saturday, May 18, 2024, during the ASPET 2024 Annual Meeting in Arlington, Va. Dr. Guo will present a lecture on her work as part of the annual meeting.
Division for Toxicology Early Career Award
Shuo Xiao, PhD
ASPET is pleased to award Dr. Shuo Xiao, PhD from Rutgers University, the 2024 Division for Toxicology Early Career Award. The ASPET Division for Toxicology established this award to recognize excellent original research by early career investigators in the area of toxicology.
Dr. Xiao is receiving this award in recognition for his innovative research and development of new technologies that have led to the discovery of fundamental and transformative concepts regarding female reproductive health through research in biology, emerging environmental toxicology, use of reproductive-tract-on-a-chip technologies as well as new drug development for family planning.
Dr. Shuo Xiao received his PhD in Toxicology from the University of Georgia and completed his postdoctoral training at Northwestern University. He is now an Assistant Professor in the Ernest Mario School of Pharmacy and the Environmental and Occupational Health Sciences Institute at Rutgers University. Dr. Xiao’s research focuses on female reproductive biology, disease, and toxicology, including (1) the side effects of anti-cancer drugs on young female cancer patients’ fertility and developing associated fertility preservation strategy, (2) impacts of emerging endocrine disrupting chemicals on women’s reproductive health, (3) engineering an ovary-on-a-chip and an entire female reproductive system-on-a-chip using microfluidic technology to study reproductive biology, medicine, and toxicology, and (4) development of novel non-hormonal contraceptive drugs targeting ovulation. Dr. Xiao has published over 60 publications in high impact peer-review journals and is very well funded by NIH, NSF, DOD, and other private research foundations. Dr. Xiao has been a member of ASPET since 2022.
The award will be presented by the Division for Toxicology on Saturday, May 18, 2024, during the ASPET 2024 Annual Meeting in Arlington, Va. Dr. Xiao will present a lecture on his work, titled “A Female Reproductive System-On-A-Chip to Study Reproductive Biology, Medicine, and Toxicology” as part of the annual meeting.
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