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FACULTY PROFILE


Renping Zhou, PhD
Professor and Department Chair
Department of Chemical Biology

Phone: (848) 445 7246
Fax: (732) 445 0687
Email: rzhou@rci.rutgers.edu

PhD, University of California

 

Bio
 
BS, Nanjing Teacher’s College, China
PhD, University of California, Berkeley, CA
Post-Doc, NCI-Frederick Cancer R&D Center, Frederick, MD
 
Research
 
Molecular mechanisms of cell differentiation; function of growth factors and their receptors in the nervous system during embryonic development and carcinogenesis; involvement of growth factors in Parkinson's Disease.

Representative Publications

Zhou R and Duesberg PH. (1989) Avian proto-myc genes promoted by defective or nondefective retroviruses are single-hit transforming genes in primary cells. Proc. Natl. Acad. Sci. USA 86:7721-7725.

Zhou R, Oskarsson M, Paules RS, Schulz N, Cleveland D, and Vande Woude GF. (1991) Ability of the c-mos product to associate with and phosphorylate tubulin.  Science 251:671-675.

Zhou R, Copeland TD, Kromer LF, and Schulz NT. (1994) Isolation and characterization of Bsk, a novel growth factor receptor-like kinase associated with the limbic system. J. Neurosci. Res. 37:129-143.

Gao P-P, Zhang J-H, Yokoyama M, Dreyfus CF, Black IB, and Zhou R. (1996) Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal system. Proc. Natl. Acad. Sci. USA 93:11161-11166.

Zhang JH, Cerritti DP, Yu T, Flanagan JG, and Zhou R. (1996) Detection of ligands in regions anatomically connected to neurons expressing the Eph receptor Bsk: potential roles in neuron-target interaction. J. Neuroscience 16:7182-7190.

Gao P-P, Yue Y, Zhang J-H, Cerritti DP, Levitt P, and Zhou R. (1998) Regulation of thalamic neurite outgrowth by the Eph ligand ephrin-A5: implications in the development of thalamocortical projections. Proc. Natl. Acad. Sci. USA 95:5329-5334.

Yu T, Scully S, Fox GM, Jing S, and Zhou R. (1998) Expression of GDNF family receptor components during development: implications in the mechanisms of interaction. J. Neurosci. 18:4684-4696.

Yue Y, Widmer DAJ, Halladay AK, Cerretti DP, Wagner GC, Dreyer J-L, and Zhou R. (1999) Specification of distinct dopaminergic neural pathways: roles of the Eph family receptor EphB1 and ligand ephrin-B2. J. Neurosci. 19:2090-2101.

Gao P-P, Yue Y, Cerritti DP, Dreyfus C, and Zhou R. (1999) Induction of axonal growth, branching, and degeneration by the Eph family ligands. Proc. Natl. Acad. Sci. USA 96:4073-4077.

Yue Y, Su J, Cerretti DP, Fox GM, Jing S, and Zhou R. (1999) Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5. J. Neurosci. 19:10026-10035.

Yue Y, Chen Z-Y, Gale NW, Blair-Flynn J, Hu T-J, Yue X, Cooper M, Crockett DP, Yancopoulos GD, Tessarollo L, and Zhou R. (2002) Mistargeting hippocampal axons by expression of a truncated Eph receptor. Proc. Natl. Acad. Sci. USA 99:10777-10782.

Hu Z, Yue X, Yue Y, Crockett DP, Egger  MD, Tessorollo L, and Zhou R. (2003) Corpus Callosum Deficiency in Transgenic Mice Expressing A Truncated EphA5 Receptor. J. Neuosci. 23: 10963-10970.

Chen ZY, Sun C, Bergemann A, Henkemeyer M, and Zhou R. (2004) Regulation of Hippocampal Axon Defasciculation by EphB Receptor Tyrosine Kinases. J. Neurosci. 24: 2366-2374.

Halladay AK, Tessarollo L, Zhou R, Wagner GC. (2004) eurochemical and behavioral deficits consequent to expression of a dominant negative EphA5 receptor. Brain Res Mol Brain Res. 123:104-111.

Hu Z, Cooper M, Crockett DP, and Zhou R. (2004) Differentiation of the midbrain dopaminergic pathways during mouse development. J. Comp. Neurol. 476: 301-311.

Yue X, Dreyfus C, Kong TA, Zhou R. (2008) A subset of signal transduction pathways is required for hippocampal growth cone collapse induced by ephrin-A5. Dev Neurobiol. 2008 68:1269-86.

Mamiya PC, Hennesy Z, Zhou R, Wagner GC (2008) Changes in attack behavior and activity in EphA5 knockout mice. Brain Res. 1205:91-9. 

 Cooper M*, Son AI, Komlos D, Sun Y, Kleiman NJ, Zhou R (2008) Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract. *co-first authors. PNAS 105:16620-16625.

Cooper M, Kobayashi K, and Zhou R (2009) Ephrin-A5 Regulates the Formation of the Ascending Midbrain Dopaminergic Pathways. Dev Neurobiol 69:36-46.

Hu T, Shi G, Larose L, Rivera GM, Mayer BJ, Zhou R (2009) Regulation of process retraction and cell migration by EphA3 Is mediated by the adaptor protein Nck1.  Biochemistry 48: 6369-6378.

Shi G, Yue G, and Zhou R (2010) EphA3 functions are regulated by collaborating phosphotyrosine residues.  Cell Res. 20: 1263-75.

Park JE, Son AI, Hua R, Wang L, Zhang X, Zhou R (2012) Human cataract mutations in EPHA2 SAM domain alter receptor stability and function. PLoS One. 2012;7(5):e36564. Epub 2012 May 3.

Sheleg M, Yochum CL, Wagner GC, Richardson JR, Zhou R (2013) Ephrin-A5 deficiency alters sensorimotor and monoaminergic development. Behav Brain Res Vol 236C:139-147.

Formation of Persistent Hyperplastic Primary Vitreous in Ephrin-A5-/- Mice. (2014) Son AI, Sheleg M, Cooper MA, Sun Y, Kleiman NJ, Zhou R. Invest Ophthalmol Vis Sci. 2014 Feb 18. pii: iovs.13-12706v1. doi: 10.1167/iovs.13-12706. [Epub ahead of print]