XI ZHENG, Assistant Research Professor
Room: LCR 217
Phone: (732) 445-3400 x233
xizheng@rci.rutgers.edu

Research Interests

Anticancer effects of naturally occurring compounds including the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Mechanisms of carcinogenesis and mechanisms of cancer chemoprevention including studies on human prostate and pancreas cancer in cell culture and animal models.

Recent Publications

Khor TO, Keum YS, Lin W, Kim JH, Hu R, Shen G, Xu C, Gopalakrishnan A, Reddy B, Zheng X, Conney AH, Kong AN. Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Res. 2006 Jan 15;66(2):613-21.

Hansson A, Marin YE, Suh J, Rabson AB, Chen S, Huberman E, Chang RL, Conney AH, Zheng X. Enhancement of TPA-induced growth inhibition and apoptosis in myeloid leukemia cells by BAY 11-7082, an NF-kappa B inhibitor. Int J Oncol. 2005 Oct;27(4):941-8.

Avila GE, Zheng X, Cui XX, Ryan AD, Hansson A, Suh J, Rabson AB, Chang RL, Shih WJ, Lin Y, Crowell P, Lu YP, Lou YR, Conney AH. Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice. J Pharmacol Exp Ther. 2005 Oct;315(1):170-87.

Zheng X, Ryan A, Patel N, Klemons S, Hansson A, Shih WJ, Lin Y, Huberman E, Chang RL, Conney AH. Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cells. Int J Oncol. 2005 Feb;26(2):441-8.

Zheng X, Chang RL, Cui XX, Avila GE, Lee S, Lu YP, Lou YR, Shih WJ, Lin Y, Reuhl K, Newmark H, Rabson A, Conney AH. Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans-retinoic acid on the growth of LNCaP prostate tumors in immunodeficient mice. Cancer Res. 2004 Mar 1;64(5):1811-20.

Cui XX, Chang RL, Zheng X, Woodward D, Strair R, Conney AH. A sensitive bioassay for measuring blood levels of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients: preliminary pharmacokinetic studies. Oncol Res. 2002;13(3):169-74.

Zheng X, Ravatn R, Lin Y, Shih WC, Rabson A, Strair R, Huberman E, Conney A, Chin KV. Gene expression of TPA induced differentiation in HL-60 cells by DNA microarray analysis. Nucleic Acids Res. 2002 Oct 15;30(20):4489-99.

Zheng X, Chang RL, Cui XX, Kelly KA, Shih WJ, Lin Y, Strair R, Suh J, Han ZT, Rabson A, Conney AH. Synergistic effects of clinically achievable concentrations of 12-O-tetradecanoylphorbol-13-acetate in combination with all-trans retinoic acid, 1alpha,25 dihydroxyvitamin D3, and sodium butyrate on differentiation in HL-60 cells. Oncol Res. 2001;12(9-10):419-27.