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FACULTY PROFILE

Andrew Gow, PhD
Associate Professor
Department of Pharmacology and Toxicology

Phone: (848) 445 4612
Fax: (732) 445 0119
Email: gow@rci.rutgers.edu

PhD, Temple University

 

Bio

BSc,  (Hons)  University of Edinburgh, Edinburgh, Scotland, UK
MEd,  Temple University, Philadelphia, PA
PhD, Temple University, Philadelphia, PA
Post-Doc, University of Pennsylvania, PA

Research

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions.  We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism.  In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes.  We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia.  It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.

Representative Publications

Guo CJ, Atochina-Vasserman E, Abramova E, Foley JP, Zaman A, Crouch E, Beers MF, Savani RC, Gow AJ. S-nitrosylation of surfactant protein-D controls inflammatory function. PLoS Biology (in press).

Davis CW, Gonzales LW, Ballard RA, Ballard PL, Guo CJ, Gow AJ.  Expression of nitric oxide synthases and endogenous NO metabolism in bronchopulmonary dysplasia. Ped. Pulmunol. 43:703-9, 2008.

Atochina-Vasserman EN, Beers MF, Kadire H, Tomer Y, Inch A, Scott P, Guo CJ, Gow AJ. Selective inhibtion of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice. J. Immunol. 179:8090-7, 2008.

Zhou S, Olson JS, Fabian M, Weiss MJ, Gow AJ. Biochemical fates of alpha hemoglobin bound to alpha-hemoglobin stability protein AHSP. J. Biol. Chem. 281:32611-8, 2006.

Allen JD, Cobb FR, Kraus WE, Gow AJ. Total nitrogen oxide following exercise testing reflects endothelial function and discriminates health status.  Free Radic. Biol. Med. 41:740-7, 2006.

Awards and Honors

1993-95     Russell Conwell Research Fellowship
1995-97     National Research Service Award, National Institutes of Health-NHLBI in Lung Cell and          
                  Molecular Biology
1996          Young Investigator Award, Oxygen Society
1997          Young Investigator Award, International Nitric Oxide Society
1998          Chartered Chemist, Royal Society of Chemistry
2000          Translational Medicine Award, Duke University
2001          Florence R.C. Murray Fellowship