Debra Laskin, PhD
Distinguished Professor and Roy A Bowers Endowed Chair
Chair of the Department of Pharmacology and Toxicology
Phone: (848) 445 5862
Fax: (732) 445 2534
PhD, Medical College of Virginia, VCU
BA, New York University, New York, NY
MA, City University of New York and the American Museum of Natural History, New York, NY
PhD, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
Post-Doc, Wistar Institute of Anatomy and Biology, University of Pennsylvania, Philadelphia, PA
Nonspecific immunity and inflammation; role of activated macrophages and inflammatory mediators in the pathophysiology of xenobiotic-induced liver and lung injury. Studies on biochemical and molecular mechanisms underlying macrophage and neutrophil activation and functional activity.
Chen, L.C., Gordon, R.E., Laskin, J.D., and Laskin, D.L. (2007). Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia. Experimental and Molecular Pathology, 83: 311-326.
Sunil, V.R., Patel, K.J., Nielson-Hamilton, M., Laskin, J.D., and Laskin, D.L. (2007). Induction of lipocalin 24p3 in lung and liver during acute endotoxemia. Experimental and Molecular Pathology, 83: 177-187.
Fakhrzadeh, L., Laskin, J.D., and Laskin, D.L. (2008). Regulation of caveolin-1 expression, nitric oxide production and oxidant-induced tissue injury by tumor necrosis factor-alpha following ozone inhalation. Toxicology and Applied Pharmacology, 227: 380-389.
Chen, L.C., Gordon, M., Laskin, J.D., and Laskin, D.L. (2008). Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Experimental and Molecular Pathology, 84:145-155.
Black, A.T., Gray, J.P. Sharkajian, M.P., Mishin, V., Laskin, D.L., Heck, D.E., Laskin J.D. (2008). UVB upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicology and Applied Pharmacology, 232: 14-24.
Laskin, D.L. (2009). Macrophages and inflammatory mediators
in chemical toxicity: A battle of
forces? Chemical Research in Toxicology,
Gardner, C.R., Gray, J.P., Joseph, L.B.,
Cervelli, J., Bremer, N., Kim, Y., Mishin, V., Laskin, J.D., Laskin, D.L. (2010).
Potential role of caveolin-1 in acetaminophen-induced
hepatotoxicity. Toxicology and Applied
Pharmacology, 245: 36-46.
A.M., Laskin, D.L., Archer, F., Syed K., Gray, J.P., Laskin, J.D.,
Nwebube, N., Weinberger, B. (2010). Inflammatory effects of phthalates in neonatal
neutrophils. Pediatric Research, 68:
Laskin, D.L. and Laskin, J.D. (2010). Inflammation and
Cancer. In: Cancer Medicine, 8th edition. W.K. Hong, R.C. Bast, W.N.
Hait, D.W. Kufe, R.E. Pollock, R.R. Weichselbaum, J.F. Holland, E. Frei, eds.,
New York: PMPH Publishing House, pp. 270-278.
Laskin, D.L., Sunil, V.R., and Laskin, J.D. (2011). Macrophages in tissue injury: agents
of defense or destruction? Annual Review
of Pharmacology and Toxicology, 51, 267-288.
Awards and Honors
2009 Rutgers University Board of Trustees Award for
Excellence in Research (2009)
Roy Bowers Endowed Chair, Ernest
Dolph Adams Award from the Society for Leukocyte Biology for the most cited
in the Journal of Leukocyte Biology during the past five years entitled
“Production of Nitric Oxide and Peroxynitrite in the Lung During
1993-98 Burroughs Wellcome Toxicology Scholar
1991 Society of Toxicology
Society for Leukocyte Biology Young Investigator Research Award
Board of Publications Award (formerly Frank R. Blood Award), Society of Toxicology
for the best research publication of the year in Toxicology and Applied
entitled: "Potential Role of Macrophages in Hepatotoxicity"