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FACULTY PROFILE

   

Debra Laskin, PhD
Distinguished Professor and Roy A Bowers Endowed Chair 
Chair of the Department of Pharmacology and Toxicology

Phone: (848) 445 5862
Fax: (732) 445 2534
Email: laskin@eohsi.rutgers.edu

PhD, Medical College of Virginia, VCU

Bio

BA, New York University, New York, NY
MA, City University of New York and the American Museum of Natural History, New York, NY
PhD, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
Post-Doc, Wistar Institute of Anatomy and Biology, University of Pennsylvania, Philadelphia, PA

Research

Nonspecific immunity and inflammation; role of activated macrophages and inflammatory mediators in the pathophysiology of xenobiotic-induced liver and lung injury. Studies on biochemical and molecular mechanisms underlying macrophage and neutrophil activation and functional activity.

Representative Publications

Chen, L.C., Gordon, R.E., Laskin, J.D., and Laskin, D.L. (2007). Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia.  Experimental and Molecular Pathology, 83: 311-326.

Sunil, V.R., Patel, K.J., Nielson-Hamilton, M., Laskin, J.D., and Laskin, D.L. (2007).  Induction of lipocalin 24p3 in lung and liver during acute endotoxemia. Experimental and Molecular Pathology, 83: 177-187.

Fakhrzadeh, L., Laskin, J.D., and Laskin, D.L.  (2008). Regulation of caveolin-1 expression, nitric oxide production and oxidant-induced tissue injury by tumor necrosis factor-alpha following ozone inhalation. Toxicology and Applied Pharmacology, 227: 380-389.

Chen, L.C., Gordon, M., Laskin, J.D., and Laskin, D.L. (2008). Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia.  Experimental and Molecular Pathology, 84:145-155.

Black, A.T., Gray, J.P. Sharkajian, M.P., Mishin, V., Laskin, D.L., Heck, D.E., Laskin J.D.  (2008). UVB upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicology and Applied Pharmacology, 232: 14-24.

Laskin, D.L. (2009). Macrophages and inflammatory mediators in chemical toxicity:  A battle of forces?  Chemical Research in Toxicology, 22: 1376-1385.

Gardner, C.R., Gray, J.P., Joseph, L.B., Cervelli, J., Bremer, N., Kim, Y., Mishin, V., Laskin, J.D., Laskin, D.L.  (2010).  Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity.  Toxicology and Applied Pharmacology, 245: 36-46.

Vetrano, A.M., Laskin, D.L., Archer, F., Syed K., Gray, J.P., Laskin, J.D., Nwebube, N., Weinberger, B. (2010). Inflammatory effects of phthalates in neonatal neutrophils.  Pediatric Research, 68: 134-139. 

Laskin, D.L. and Laskin, J.D. (2010). Inflammation and Cancer. In: Cancer Medicine, 8th edition. W.K. Hong, R.C. Bast, W.N. Hait, D.W. Kufe, R.E. Pollock, R.R. Weichselbaum, J.F. Holland, E. Frei, eds., New York: PMPH Publishing House, pp. 270-278.

Laskin, D.L., Sunil, V.R., and Laskin, J.D.  (2011). Macrophages in tissue injury: agents of defense or destruction?  Annual Review of Pharmacology and Toxicology, 51, 267-288. 

Awards and Honors

2009        Rutgers University Board of Trustees Award for Excellence in Research (2009)

2007        Roy Bowers Endowed Chair, Ernest Mario School of Pharmacy

1999        Dolph Adams Award from the Society for Leukocyte Biology for the most cited research
               publication in the Journal of Leukocyte Biology during the past five years entitled
               “Production of Nitric Oxide and Peroxynitrite in the Lung During  Endotoxema”
 
1993-98    Burroughs Wellcome Toxicology Scholar Award  
 
1991         Society of Toxicology Achievement Award

1989         Society for Leukocyte Biology Young Investigator Research Award

1988         Board of Publications Award (formerly Frank R. Blood Award), Society of Toxicology
                for the best research publication of the year in Toxicology and  Applied Pharmacology 
                entitled: "Potential Role of Macrophages in Hepatotoxicity"