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  Xi Zheng, PhD
Research Professor
Department of Chemical Biology

Phone: (848) 445 8069
Fax: (732) 445 0678

PhD, Huddinge Univ. Hospital, Karolinska Institute, Sweden


BS, Sun Yat-sen Univ. of Medical Sciences, China
PhD, Huddinge Univ. Hospital, Karolinska Institute, Sweden


Anticancer effect of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) and other naturally occurred compounds; development of effective combinations of anticancer agents for the treatment of leukemia, inhibitory effect of dietary chemicals, drugs and exercise on the development of prostate cancer.

Representative Publications

Zheng X, Chang RL, Cui XX, Avila GE, Lee S, Lu YP, Lou YR, Shih WJ, Lin
Y, Reuhl K, Newmark H, Rabson A, Conney AH. Inhibitory effect of
12-O-tetradecanoylphorbol-13-acetate alone or in combination with
all-trans-retinoic acid on the growth of LNCaP prostate tumors in
immunodeficient mice. Cancer Res. 64:1811-20, 2004.

Zheng,X., Cui, X-X. Avila, G.E., Huang, M-T., Liu, Y., Patel, J., Kong, A.N.T.,
Paulino, R., Shih, W.J., Lin, Y, Rabson, A.B., Reddy, B.S., Conney,
A.H.: Atorvastatin and Celecoxib inhibit Prostate PC-3 tumors in
immunodeficient mice. Clin. Cancer Res. 13: 5480-5487, 2007.

Zheng,X., Chang, R.L., Cui, X.X., Avila, G., Huang, M.T., Liu, Y., Kong,
A.N., Rabson, A.B., Conney, A.H.: Inhibition of NF-kappaB by
(E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is
associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced
growth suppression and apoptosis in human prostate cancer PC-3 cells.
Int J Oncol. 32:257-64, 2008.

Zheng X., Cui XX, Gao Z, Zhao Y, Lin
Y, Shih WJ, Huang MT, Liu Y, Rabson A, Reddy B, Yang CS, Conney AH.
Atorvastatin and celecoxib in combination inhibits the progression of
androgen-dependent LNCaP xenograft prostate tumors to androgen
independence. Cancer Prev Res (Phila Pa). 2010 Jan;3(1):114-24.

Huang H, He Y, Cui XX, Goodin S, Wang H, Du ZY, Li D, Zhang K, Tony Kong AN, DiPaola RS, Yang CS, Conney AH, Zheng X. Potent inhibitory effect of δ-tocopherol, on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo. J Agric Food Chem. 2014 Nov 5;62(44):10752-8.