Pharmacy Website

FACULTY PROFILE

 

  Xi Zheng, PhD
Research Professor
Department of Chemical Biology

Phone: (848) 445 8069
Fax: (732) 445 0678
Email: xizheng@pharmacy.rutgers.edu

PhD, Huddinge Univ. Hospital, Karolinska Institute, Sweden

Bio

BS, Sun Yat-sen Univ. of Medical Sciences, China
PhD, Huddinge Univ. Hospital, Karolinska Institute, Sweden

Research

Anticancer effect of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) and other naturally occurred compounds; development of effective combinations of anticancer agents for the treatment of leukemia, inhibitory effect of dietary chemicals, drugs and exercise on the development of prostate cancer.

Representative Publications

Zheng X, Chang RL, Cui XX, Avila GE, Lee S, Lu YP, Lou YR, Shih WJ, Lin
Y, Reuhl K, Newmark H, Rabson A, Conney AH. Inhibitory effect of
12-O-tetradecanoylphorbol-13-acetate alone or in combination with
all-trans-retinoic acid on the growth of LNCaP prostate tumors in
immunodeficient mice. Cancer Res. 64:1811-20, 2004.

Zheng,X., Cui, X-X. Avila, G.E., Huang, M-T., Liu, Y., Patel, J., Kong, A.N.T.,
Paulino, R., Shih, W.J., Lin, Y, Rabson, A.B., Reddy, B.S., Conney,
A.H.: Atorvastatin and Celecoxib inhibit Prostate PC-3 tumors in
immunodeficient mice. Clin. Cancer Res. 13: 5480-5487, 2007.

Zheng,X., Chang, R.L., Cui, X.X., Avila, G., Huang, M.T., Liu, Y., Kong,
A.N., Rabson, A.B., Conney, A.H.: Inhibition of NF-kappaB by
(E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is
associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced
growth suppression and apoptosis in human prostate cancer PC-3 cells.
Int J Oncol. 32:257-64, 2008.

Zheng X., Cui XX, Gao Z, Zhao Y, Lin
Y, Shih WJ, Huang MT, Liu Y, Rabson A, Reddy B, Yang CS, Conney AH.
Atorvastatin and celecoxib in combination inhibits the progression of
androgen-dependent LNCaP xenograft prostate tumors to androgen
independence. Cancer Prev Res (Phila Pa). 2010 Jan;3(1):114-24.

Zheng X., Cui XX, Gao Z, Zhao Y, Shi Y, Huang MT, Liu Y, Wagner GC, Lin Y,
Shih WJ, Rao CV, Yang CS, Conney AH. Inhibitory effect of dietary
atorvastatin and celecoxib together with voluntary running wheel
exercise on the progression of androgen-dependent LNCaP prostate tumors
to androgen independence. Exp Ther Med. 2011 Mar;2(2):221-228.