Pharmacy Website

FACULTY PROFILE

Paul E. Thomas, PhD
Professor
Department of Chemical Biology

Phone: (732) 445 0142
Fax: (732) 445 0119
Email: pethomas@eohsi.rutgers.edu

PhD, The Ohio State University

Bio

BS, Otterbein College, Westerville, OH
         College of Orlando, Orlando, FL
PhD, The Ohio State University, Columbus, OH

Research

Proteomics; breast cancer mechanism and prevention research; monoclonal and polyclonal antibodies to cytochrome P-450 isozymes as a means to study their tissue distribution, regulation of expression, membrane topology, structure/function and epitope mapping; mechanisms of drug and xenobiotic toxicity.

Representative Publications

Lee HJ, Paul S, Atalla N, Thomas PE, Lin X, Yang I, Buckley
B, Lu G, Zheng X, Lou YR, Conney AH, Maehr H, Adorini L, Uskokovic M, Suh N.
Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen
receptor-negative mammary tumorigenesis without hypercalcemic toxicity. Cancer
Prev Res (Phila Pa). 1:476-84. 2008.

Jan YH, Mishin V, Busch CM, Thomas PE. Generation of specific antibodies and
their use to characterize sex differences in four rat P450 3A enzymes following
vehicle and pregnenolone 16alpha-carbonitrile treatment. Arch Biochem Biophys.
446:101-10, 2006.

Gu X, Ke S, Liu D, Sheng T, Thomas PE, Rabson AB, Gallo MA, Xie W, Tian Y. Role
of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the
suppression of cytochrome P-450 3A4 by proinflammatory agents. J Biol Chem.
281:17882-9, 2006.

Hong M, Li S, Zhou F, Thomas PE, You G.  Putative Transmembrane Domain 12
of the Human Organic Anion Transporter hOAT1 Determines Transporter Stability
and Maturation Efficiency. J Pharmacol Exp Ther. 332(2):650-8, 2010.

Parimoo B, Mishin VM, Busch CM, Thomas PE. Identification of epitopes on
cytochrome P450 3A4/5 recognized by monoclonal antibodies. Arch Biochem
Biophys. 414:244-54, 2003.