Pharmacy Website

FACULTY PROFILE

Tamara Minko, PhD
Distinguished Professor and Chair
Department of Pharmaceutics

Phone: (848) 445 6348
Fax: (732) 445 3134
Email: minko@rci.rutgers.edu

 

Bio

Dr. Tamara Minko is a Professor II and Chair at the Department of Pharmaceutics. Professor Minko is an author and co-author of more than 400 publications including peer-reviewed papers, book and textbook chapters, and conference proceedings. Many of her papers are well cited and published in prestigious journals with high impact factors including PNAS, Nature Nanotechnology, Cancer Research, Advanced Drug Delivery Review, Journal of Controlled Release, Small, ACS Nano, etc. Dr. Minko served as a CRS Bioactive Materials Track Program Chair in 2009. She is a Member of Board of Scientific Advisors of the Controlled Release Society, AAPS Fellow, recipient of numerous awards, Editor of Pharmaceutical Research, member of editorial board of seven scientific journals and a member of Study Sections at NIH, DOD and other review panels. Her research is supported by grants from NIH, NSF, DOD and other national and international sources.

Links

http://web.rutgers.edu/pharmsci/facultyminko.htm

http://ceutics.rutgers.edu/minkohome.shtml

Research

Tamara Minko’s current research interests include biopharmaceutics; targeted drug delivery; nanotechnology (polymers, dendrimers, liposomes, etc.) for cancer detection and treatment; molecular targeting; non-viral nanoscale-based delivery of antisense oligonucleotides, siRNA and peptides; mechanisms of multidrug resistance; intracellular fate and molecular mechanisms of action of anticancer drugs: apoptosis and necrosis, signal transduction, antiapoptotic cellular defensive mechanisms; use of macromolecules for drug delivery; preclinical evaluation of anticancer drugs; tumor hypoxia; modulation of cell death mechanisms during hypoxia.

Representative Publications

M. L. Patil, M. Zhang, O. B. Garbuzenko, T. Minko, Multifunctional triblock nanocarrier (PAMAM-PEG-PLL) for the efficient intracellular delivery of siRNA and potent gene silencing, ACS Nano, 5, 1877-1887 (2011).

O. B. Garbuzenko, M. Saad, V. P. Pozharov, K. R. Reuhl, G. Mainelis, T. Minko, Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance, Proc. Natl. Acad. Sci. USA, 107, 10737-10742 (2010).

P. Chandna, J. J. Khandare, E. Ber, L. Rodriguez-Rodriguez, T. Minko, Targeted multicomponent polymer-peptide-drug conjugates for treatment of primary and metastatic cancers, Pharm. Res., 27, 2296-2306 (2010).

M. Saad, O. B. Garbuzenko, E. Ber, P. Chandna, J. J. Khandare, V. P. Pozharov, T. Minko, Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the most efficient for tumor-specific treatment and imaging? J. Control. Release, 130, 107-114 (2008).

Y. Wang, M. Saad, R. I. Pakunlu, J. J. Khandare, O. B. Garbuzenko, A. A. Vetcher, V. A. Soldatenkov, V. P. Pozharov, T. Minko, Non-viral nanoscale-based delivery of antisense oligonucleotides targeted to HIF1 alpha enhances the efficacy of chemotherapy in drug resistant tumor, Clin. Cancer Res., 14, 3607-3616 (2008).

Awards and Honors

Member (Elected), Board of Scientific Advisors, Controlled Release Society, 2010-Present.

Fellow (Elected) of the American Association of Pharmaceutical Scientists (AAPS) (2009).

Controlled Release Society Awards: Controlled Release Society Outstanding Pharmaceutical Paper Awards: 2008 (S. Betigeri, O. B. Garbuzenko, T. Minko);  2010 (O. Taratula, O. B. Garbuzenko, P. Kirkpatrick, I. Pandya, R. Savla, V. P. Pozharov, H. He, T. Minko); 2011 (O. Taratula, M. Shah, O. Garbuzenko, T. Minko); Controlled Release Society Outstanding Student Poster Award (P. Chandna, Graduate Student of T. Minko), 2008; Journal of Controlled Release/Controlled Release Society 1998 Outstanding Paper Award (T. Minko, V. Pozharov, P. Kopeckova, J. Kopecek).

American Association of Pharmaceutical Scientists (AAPS) Awards: AAPS Physical Pharmacy and Biopharmaceutics (PPB) Graduate Student Award (M. Zhang, Graduate Student of T. Minko), 2009; AAPS Biotechnology Graduate Student Award (P.Chandna, Graduate Student of T. Minko), 2008; AAiPS Research Award for the Contribution to Research in the Pharmaceutical Sciences (P. Chandna, Graduate Student of T. Minko), 2008; AAPS Biotechnology Graduate Student Award (S. Betigeri, Graduate Student of T. Minko), 2007; AAiPS Research Award for the Contribution to Research in the Pharmaceutical Sciences (S. Betigeri, Graduate Student of T. Minko), 2007; AAiPS Research Award for the Contribution to Research in the Pharmaceutical Sciences (P. Chandna, Graduate Student of T. Minko), 2005; AAPS Biotechnology Graduate Student Award (S. S. Dharap, Graduate Student of T. Minko), 2003; AAiPS Research Award for the Contribution to Research in the Pharmaceutical Sciences (S. S. Dharap, Graduate Student of T. Minko), 2002.

Gallo Award for Scientific Excellence, The Cancer Institute of New Jersey for Outstanding Cancer Research (O. Garbuzenko, O. Taratula, T. Minko), 2011; The New Jersey Cancer Research Award for Scientific Excellence (O. Taratula, O. B. Garbuzenko, R. Savla, H. He, T. Minko), 2009; Gallo Award for Scientific Excellence, Presented by The Cancer Institute of New Jersey for Outstanding Cancer Research, 2008 (M. Saad, Graduate Student of T. Minko) and (O. Taratula, Graduate Student of T. Minko and H. He).

New Jersey Pharmaceutical Association for Science and Technology 2010 Student Scholarship Award (M. Zhang, Graduate Student of T. Minko), 2010.

First Place Poster Award, The Biennial New Jersey Pharmaceutical Conference (M. Zhang, O. Garbuzenko, L. Rodriguez, T. Minko), 2009; Second Place Poster Award, The Biennial New Jersey Pharmaceutical Conference (O. Taratula, O. Garbuzenko, Z. Wang, G. Mainelis, T. Minko), 2009.

Excellence Award from the 21st Annual International Symposium “Frontiers of Nanotechnology & Biotechnology: Integration and Invention” (O. Taratula, Graduate Student of T. Minko and H. He), 2008.

The Outstanding Excellence Awards for the best paper presentations in the 27th Anniversary Conference, GRASP 2007 (Oleh Taratula, Graduate Student of T. Minko and H. He), 2007; The Outstanding Excellence Awards for the best paper presentations in the 25th Anniversary Conference, GRASP 2005 (Seema Betigeri and Pooja Chandna, Graduate Students of T. Minko), 2005.

The First Place Advanced Drug Delivery Charles A. Stevens Memorial Award at the Philadelphia Pharmaceutical Forum (R. I. Pakunlu, Graduate Student of T. Minko), 2006; The First Place Biotechnology Charles A. Stevens Memorial Award at the Philadelphia Pharmaceutical Forum (Y. Wang, Graduate Student of T. Minko), 2005; Charles A. Stevens Memorial Awards (The First Place) at the Philadelphia Pharmaceutical Forum (S. S. Dharap, Graduate Student of T. Minko), 2003;  Charles A. Stevens Memorial Awards (The Second Place) at the Philadelphia Pharmaceutical Forum (S. S. Dharap, Graduate Student of T. Minko), 2002.

Award for an Outstanding Achievement from International Journal of Oncology, Oncology Reports and International Journal of Molecular Medicine, 2002.

Highlighted papers or featured as the Most-Accessed Articles: Proc. Natl. Acad. Sci. USA, 2010; Pharm. Res, 2010; Nanomedicine, 2008; Bioconjugate Chem., 2008; J. Controlled Rel., 2008; Mol. Pharm, 2007; Nature Nanotech., 2007; J. Controlled Rel., 2006; Prog. Polym. Sci, 2006; Bioconjugate Chem., 2006; Proc. Natl. Acad. Sci. USA, 2005; Cancer Res., 2004; J. Controlled Rel., 2003; Pharm. Res., 2003; J. Appl. Physiol, 2002; Int. J. Cancer, 2000; Pharm. Res, 1999; J. Controlled Rel., 1998.