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FACULTY PROFILE

Tamara Minko, PhD
Distinguished Professor and Chair
Department of Pharmaceutics

Phone: (848) 445 6348
Fax: (732) 445 3134
Email: minko@rci.rutgers.edu

 

Bio

Dr. Tamara Minko is a Distinguished Professor and Chair of the Department of Pharmaceutics at Rutgers, The State University of New Jersey, a member of the Cancer Institute of New Jersey and Environmental and Occupational Health Sciences Institute. Dr. Minko’s current research interests include nanoscale-based targeted delivery of drugs, peptides, siRNA and antisense oligonucleotides in order to enhance the efficiency of treatment and imaging; nanoparticle formulation, characterization and testing; preclinical in vitro and in vivo evaluation of anticancer therapeutics; orthotopic and ectopic animal models of cancer, lung diseases and fibrosis; personalized medicine; hypoxia; mechanisms of multidrug resistance and their suppression; intracellular fate and molecular mechanisms of action of drugs; pharmacokinetics and pharmacodynamics. She is an author and co-author of more than 400 publications (peer-reviewed papers, books and textbook chapters, conference proceedings/abstracts, and patents). Many of her papers are well cited and published in prestigious journals with high impact factors including PNAS, Nature Nanotechnology, Cancer Research, Clinical Cancer Research, Advanced Drug Delivery Review, Journal of Controlled Release, Small, ACS Nano, etc (http://scholar.google.com/citations?user=G7_qz4kAAAAJ&hl=en&oi=ao). Dr. Minko is a Fellow of AAPS, CRS and AIMBE, recipient of numerous awards, Executive Editor of Advanced Drug Delivery Reviews, Editor of Pharmaceutical Research, member of editorial board of ten scientific journals and a member of Study Sections at NIH, DOD, American Heart Association and other national and international review panels. Her research is supported by grants from NIH, NSF, DOD and other national and international sources.

Links

http://scholar.google.com/citations?user=G7_qz4kAAAAJ&hl=en&oi=ao

http://minkolab.com/index.aspx

Research

Tamara Minko’s current research interests include nanoscale-based targeted delivery of drugs, peptides, siRNA and antisense oligonucleotides in order to enhance the efficiency of treatment and imaging; nanoparticle formulation, characterization and testing; preclinical in vitro and in vivo evaluation of anticancer therapeutics; orthotopic and ectopic animal models of cancer, lung diseases and fibrosis; personalized medicine; hypoxia; mechanisms of multidrug resistance and their suppression; intracellular fate and molecular mechanisms of action of drugs; pharmacokinetics and pharmacodynamics.

Representative Publications

T. Minko, L. Rodriguez-Rodriguez, V. Pozharov, Nanotechnology approaches for personalized treatment of multidrug resistant cancers, Adv Drug Deliv Rev, 65, 1880-1895 (2013).

V. Shah, O. Taratula, O. B. Garbuzenko, O. R. Taratula, L. Rodriguez-Rodriguez, T.  Minko, Targeted Nanomedicine for Suppression of CD44 and Simultaneous Cell Death Induction in Ovarian Cancer: an Optimal Delivery of siRNA and Anticancer Drug, Clin. Cancer Res., 19, 6193-6204 (2013).

M. L. Patil, M. Zhang, O. B. Garbuzenko, T. Minko, Multifunctional triblock nanocarrier (PAMAM-PEG-PLL) for the efficient intracellular delivery of siRNA and potent gene silencing, ACS Nano, 5, 1877-1887 (2011).

O. B. Garbuzenko, M. Saad, V. P. Pozharov, K. R. Reuhl, G. Mainelis, T. Minko, Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance, Proc. Natl. Acad. Sci. USA, 107, 10737-10742 (2010).

M. Saad, O. B. Garbuzenko, E. Ber, P. Chandna, J. J. Khandare, V. P. Pozharov, T. Minko, Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the most efficient for tumor-specific treatment and imaging? J. Control. Release, 130, 107-114 (2008).

Awards and Honors

2015 New Jersey Health Foundation Excellence in Research Award.

Fellow (Elected), Controlled Release Society (CRS), 2014 – Present.

Fellow (Elected), American Institute for Medical and Biological Engineering (AIMBE), 2014 – Present.

Fellow (Elected) of the American Association of Pharmaceutical Scientists (AAPS), 2009 – Present.

Controlled Release Society Awards: Controlled Release Society Outstanding Pharmaceutical Paper Awards: 2008 (S. Betigeri, O. B. Garbuzenko, T. Minko);  2010 (O. Taratula, O. B. Garbuzenko, P. Kirkpatrick, I. Pandya, R. Savla, V. P. Pozharov, H. He, T. Minko); 2011 (O. Taratula, M. Shah, O. Garbuzenko, T. Minko); Controlled Release Society Outstanding Student Poster Award (P. Chandna, Graduate Student of T. Minko), 2008; Journal of Controlled Release/Controlled Release Society 1998 Outstanding Paper Award (T. Minko, V. Pozharov, P. Kopeckova, J. Kopecek); Elected Member, Board of Scientific Advisors, 2010-2011; Elected Member, Board of Directors and Member-st-Large, 2011-2014.

American Association of Pharmaceutical Scientists (AAPS) Awards: AAPS Physical Pharmacy and Biopharmaceutics (PPB) Graduate Student Award (M. Zhang, Graduate Student of T. Minko), 2009; AAPS Biotechnology Graduate Student Award (P.Chandna, Graduate Student of T. Minko), 2008; AAiPS Research Award for the Contribution to Research in the Pharmaceutical Sciences (P. Chandna, Graduate Student of T. Minko), 2008; AAPS Biotechnology Graduate Student Award (S. Betigeri, Graduate Student of T. Minko), 2007; AAiPS Research Award for the Contribution to Research in the Pharmaceutical Sciences (S. Betigeri, Graduate Student of T. Minko), 2007; AAiPS Research Award for the Contribution to Research in the Pharmaceutical Sciences (P. Chandna, Graduate Student of T. Minko), 2005; AAPS Biotechnology Graduate Student Award (S. S. Dharap, Graduate Student of T. Minko), 2003; AAiPS Research Award for the Contribution to Research in the Pharmaceutical Sciences (S. S. Dharap, Graduate Student of T. Minko), 2002.

Rutgers 2012 Most Innovative Technology Award (T. Minko, O. Garbuzenko, M. Zhang, L, Rodriguez), 2012.

Gallo Award for Scientific Excellence, The Cancer Institute of New Jersey for Outstanding Cancer Research (O. Garbuzenko, O. Taratula, T. Minko), 2011; The New Jersey Cancer Research Award for Scientific Excellence (O. Taratula, O. B. Garbuzenko, R. Savla, H. He, T. Minko), 2009; Gallo Award for Scientific Excellence, Presented by The Cancer Institute of New Jersey for Outstanding Cancer Research, 2008 (M. Saad, Graduate Student of T. Minko) and (O. Taratula, Graduate Student of T. Minko and H. He).

New Jersey Pharmaceutical Association for Science and Technology 2010 Student Scholarship Award (M. Zhang, Graduate Student of T. Minko), 2010.

First Place Poster Award, The Biennial New Jersey Pharmaceutical Conference (M. Zhang, O. Garbuzenko, L. Rodriguez, T. Minko), 2009; Second Place Poster Award, The Biennial New Jersey Pharmaceutical Conference (O. Taratula, O. Garbuzenko, Z. Wang, G. Mainelis, T. Minko), 2009.

Excellence Award from the 21st Annual International Symposium “Frontiers of Nanotechnology & Biotechnology: Integration and Invention” (O. Taratula, Graduate Student of T. Minko and H. He), 2008.
 
The Outstanding Excellence Awards for the best paper presentations in the 27th Anniversary Conference, GRASP 2007 (Oleh Taratula, Graduate Student of T. Minko and H. He), 2007; The Outstanding Excellence Awards for the best paper presentations in the 25th Anniversary Conference, GRASP 2005 (Seema Betigeri and Pooja Chandna, Graduate Students of T. Minko), 2005.
 
The First Place Advanced Drug Delivery Charles A. Stevens Memorial Award at the Philadelphia Pharmaceutical Forum (R. I.  Pakunlu, Graduate Student of T. Minko), 2006; The First Place Biotechnology Charles A. Stevens Memorial Award at the Philadelphia Pharmaceutical Forum (Y. Wang, Graduate Student of T. Minko), 2005; Charles A. Stevens Memorial Awards (The First Place) at the Philadelphia Pharmaceutical Forum (S. S. Dharap, Graduate Student of T. Minko), 2003;  Charles A. Stevens Memorial Awards (The Second Place) at the Philadelphia Pharmaceutical Forum (S. S. Dharap, Graduate Student of T. Minko), 2002.

Award for an Outstanding Achievement from International Journal of Oncology, Oncology Reports and International Journal of Molecular Medicine, 2002.

Highlighted papers or featured as the Most-Accessed Articles: Clin. Cancer Res., 2013; J. Controlled. Rel., 2013; J Aerosol Med Pulm Drug Deliv, 2013; Proc. Natl. Acad. Sci. USA, 2010; Pharm. Res, 2010; Nanomedicine, 2008; Bioconjugate Chem., 2008; J. Controlled Rel., 2008; Mol. Pharm, 2007; Nature Nanotech., 2007; J. Controlled Rel., 2006; Prog. Polym. Sci, 2006; Bioconjugate Chem., 2006; Proc. Natl. Acad. Sci. USA, 2005; Cancer Res., 2004; J. Controlled Rel., 2003; Pharm. Res., 2003; J. Appl. Physiol, 2002; Int. J. Cancer, 2000; Pharm. Res, 1999; J. Controlled Rel., 1998.