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Tamara Minko, PhD Phone: (732) 445 3831 x214 |
Bio
Dr. Tamara Minko is a Professor and Chair at the Department of Pharmaceutics and Acting Director of Graduate Program in Pharmaceutical Science. Professor Minko is an author and co-author of more than 85 peer-reviewed papers, 16 book and textbook chapters and more than 200 conference proceedings. Dr. Minko is an Editor of Pharmaceutical Research and member of Editorial Boards of several scientific journals. She serves as a reviewer in NIH, Department of Defense and American Heart Association Scientific Review Panels. Her research is supported by grants from National Institutes of Health, American Lung Association and several other national and international sources.
Links
http://web.rutgers.edu/pharmsci/facultyminko.htm
http://ceutics.rutgers.edu/minkohome.shtml
Research
Tamara Minko’s current research interests include drug delivery; biopharmaceutics; nanotechnology for cancer detection and treatment; molecular targeting; antisense oligonucleotides, siRNA and peptides in cancer therapy; mechanisms of multidrug resistance; intracellular fate and molecular mechanisms of action of anticancer drugs: apoptosis and necrosis, signal transduction, antiapoptotic cellular defensive mechanisms; use of macromolecules for drug delivery; preclinical evaluation of anticancer drugs; tumor hypoxia; modulation of cell death mechanisms during hypoxia.
Representative Publications
Y. Wang, M. Saad, R. I. Pakunlu, J. J. Khandare, O. B. Garbuzenko, A. A. Vetcher, V. A. Soldatenkov, V. P. Pozharov, T. Minko, Non-viral nanoscale-based delivery of antisense oligonucleotides targeted to HIF1 alpha enhances the efficacy of chemotherapy in drug resistant tumor, Clin. Cancer Res., 14, 3607-3616 (2008).
P. Chandna, M. Saad, E. Ber, J. J. Khandare, A. A. Vetcher, V. A. Soldatenkov, T. Minko, Targeted proapoptotic anticancer drug delivery system, Mol. Pharm., 4,668-678 (2007).
Y. Geng, P. Dalhaimer, S. Cai, R. Tsai, M. Tewari, T. Minko, D. E. Discher, Shape effects of filaments versus spherical particles in flow and drug delivery, Nature Nanotech., 2, 249 – 255 (2007).
J. J. Khandare, P. Chandna, Y. Wang, V. P. Pozharov, T. Minko, Novel polymeric prodrug with multivalent components for cancer therapy, J. Pharmacol. Exp. Ther., 317, 929-937 (2006).
S. S. Dharap, Y. Wang, P. Chandna, J. J. Khandare, B. Qiu, S. Gunaseelan, P. J. Sinko, S. Stein, A. V. Farmanfarmanian, T. Minko, Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide, Proc. Natl. Acad. Sci. USA, 102, 12962-12967 (2005).
Awards and Honors
Awards of the Biology and Theoretical Medicine Section of the Ukrainian Academy of Sciences (1988, 1993).
Journal of Controlled Release/Controlled Release Society Outstanding Paper Award (1998).
Award for an Outstanding Achievement from International Journal of Oncology, Oncology Reports and International Journal of Molecular Medicine (2002).
Highlighted papers or featured as the Most-Accessed Articles: Pharm. Res, 1999; J. Appl. Physiol, 2002; Pharm. Res., 2003; J. Controlled Rel., 2003; Cancer Res., 2004; Proc. Natl. Acad. Sci. USA, 2005; Bioconjugate Chem., 2006; Prog. Polym. Sci, 2006; J. Controlled Rel., 2006; Nature Nanotech., 2007; Mol. Pharm, 2007.
Graduate student awards (Minko’s Lab): Charles A. Stevens Biotechnology Memorial Awards (S. S. Dharap, 2002, 2003; Y. Wang, 2005) and Advanced Drug Delivery Memorial Award (R. I. Pakunlu, 2006); AAiPS Research Award for the Contribution to Research in the Pharmaceutical Sciences (S. S. Dharap, 2002; P. Chandna, 2005; S. Betigeri, 2007); AAPS Biotechnology Graduate Student Award (S. S. Dharap, 2003; S. Betigeri, 2007); GRASP Outstanding Excellence Awards (S. Betigeri, 2005; P. Chandna, 2005; O. Taratula, 2007); 21st Annual International Symposium “Frontiers of Nanotechnology & Biotechnology: Integration and Invention” (O. Taratula, 2008); Gallo Award for Scientific Excellence for Outstanding Cancer Research (M. Saad, 2008, O. Taratula, 2008); Controlled Release Society Outstanding Student Poster Award (P. Chandna, 2008); Controlled Release Society Outstanding Pharmaceutical Paper Award (S. Betigeri, 2008).
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