Chung S. Yang, PhD
Distinguished Professor and John L. Colaizzi Endowed Chair in Pharmacy
Phone: (848) 445 5360
Fax: (732) 445 0687
PhD, Cornell University
BS, National Taiwan University, Taipei, Taiwan
PhD, Cornell University, Ithaca, NY
Post-Doc, Scripps Clinic & Research Foundation, La Jolla, CA
Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.
- Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
- Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols and y- and δ- tocopherols.
- Investigating the mechanisms by which green and black tea prevent obesity, diabetes and other chronic diseases.
- Conduct research as described above.
- Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
- Conduct collaborative research in China and mentor youg scientists
- Serve on editorial board of several scientific journals.
Yang, C.S., Wang, X., Lu, G., Picinich, S.C. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nature Reviews Cancer 9: 429-439, 2009.
Lu, G., Xiao, H., Li, G., Chen, K.-Y., Hao, J., Loy, S. and Yang, C.S. y-tocopherols-rich mixture of tocopherols inhibits chemically-induced lung tumorigenesis in A/J mice and xenograft tumor growth. Carcinogenesis, 31: 687-694, 2010.
Lambert, J.D., Kennett, M.J., Sang, S., Reuhl, K.R., Ju, J., and Yang, C.S. Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice. Food & Chem. Toxicol., 48: 409-416, 2010.
Zhao, Y., Lee, M-J., Cheung, C., Ju, J., Chen, Y-K., Liu, B., Hu, L., and Yang, C.S. Analysis of multiple metabolites of tocopherols and tocotrienols in mice and humans. J. Agri. Food Chem. 58: 4844-4852, 2010.
Li, G-X., Chen, Y-K., Hou, Z., Xiao, H., Jin, H., Lu, G., Lee, M-J., Liu, B., Guan, F., Yang, Z., Yu, A., and Yang, C.S. Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: A comparative study in vivo and in vitro. Carcinogenesis 31: 902-910, 2010.
Cheung, C., Loy, S., Li, G.X., Liu, A.B., and Yang, C.S. Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. Carcinogenesis 32: 233-239, 2011.
Li, G.X., Lee, M-J., Liu, A.B., Yang, Z., Lin, Y., Shih, W.J., and Yang, C.S. δ-Tocopherol is more active than a- or y-tocopherol in inhibiting lung tumorigenesis in vivo. Cancer Prev. Res. 4: 404-413, 2011.
Li, G., Liu, A.B., Cheung, C., Reuhl, K.R., Bostland, M.C., and Yang, C.S. Dietary carcinogen PhIP induced prostate carcinogenesis in CYP1A-humanized mice and promotion by a high-fat stress diet. Cancer Prev. Res. 5: 963-972, 2012.
Yang, C.S. and Pan, E. The Effects of green tea polyphenols on drug metabolism. Expert Opin. Drug Metabo. Toxicol. 8: 677-689, 2012.
Li, G., Wang, H., Liu, A.B., Cheung, C., Reuhl, K.R., Bosland, M.C. and Yang, C.S. Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. Cancer Prev. Res., 5: 963-972, 2012.
Yang, Z., Lee, M-J., Sang, S., and Yang, C.S. Bioavailability and metabolism of tocotrienols. In Tocotrienols: vitamin E beyond tocopherols, 2nd Ed., (Tan, B., Watson, R.R., and Preedy, V.R., eds.), pp. 37-51, CRC Press, Boca Raton, NY, 2012.
Yang, C.S., Suh, N., and Kong, A-H. T. Does vitamin E prevent or promote cancer? Cancer Pre. Res. 5: 701-5, 2012.
Smolarek, A.K., So, J.Y., Burgess, B., Kong, A.N., Reuhl, K., Lin, Y., Shih, W.J., Li, G., Lee, M-J., Chen, Y-K., Yang, C.S., and Suh, N. Dietary administration of δ- and γ-tocopherol inhibits tumorigenesis in the animal model of estrogen receptor-positive, but not HER-2 breast cancer. Cancer Prev. Res. 5: 1310-20, 2012.
Shanafelt, T.D., Call, T.G., Zent, C.S., Leis, J.F., LaPlant, B., Bowen, D.A., Roos, M., Laumann, K., Ghosh, A.K., Lesnick, C., Lee, M-J., Yang, C.S., Jelinek, D.F., Erlichman, C., and Kay, N.E. Phase 2 trial of daily, oral polyphenone in patients with asymptomatic, rai stage 0-II chronic lymphocytic leukemia(CLL). Cancer 119: 363-70, 2013.
Yang, C.S. and Wang, H. Cancer therapy combination: green tea and a phosphodiesterase 5 inhibitor? J. Clin. Invest. 123: 556-8, 2013.
Yang, C.S. and Hong, J. Prevention of chronic diseases by tea: possible mechanisms and human relevance. Ann. Rev. Nutr. 33: 161-81, 2013.
Yang, C.S., Wang, H., and Hu, B. Combination of chemopreventive agents in nanoparticles for cancer prevention. Cancer Prev. Res. 6: 1011-1014, 2013.
Dolfi, S.C., Yang. Z., Lee M,J,, Guan, F., Hong, J., and Yang, C.S. Inhibitory effects of different forms of tocopherols, tocopherol phosphates and tocopherol quinones on growth of colon cancer cells. J Agric Food Chem. 61: 8533-40, 2013.
Cheung, K.L., Lee, J.H., Khor, T.O., Wu, T.Y., Li, G.X., Chan, J., Yang, C.S., and Kong, A.N. Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. Mol. Carcinog. 53: 77-84, 2014.
Zhu, L., Cheng, X., Ding, Y., Shi, J. Jin, H., Wu, Y., Ye, J., Lu, Y., Wang, T.C., Yang, C.S., and Tu, S.P. Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. Cancer Lett. 343: 80-9, 2014.
Zhou, J., Farah, B.L., Sinha, R.A., Wu, Y., Singh, B.K., Bay, B.H., Yang, C.S., and Yen, P.M. Epigallocatechin-3-Gallate (EGCG), a green tea polyphenol, dtimulates hepatic autophagy and lipid clearance. PLoS One. 9:e87161, 2014.
Yue, W., Yang, C.S., Dipaola, R.S., and Tan, X.L. Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. Cancer Prev. Res. 7: 388-97, 2014.
Zhu, H., Zhang, H., Jin, F., Fang, M., Huang, M., Yang, C.S., Chen, T., Fu, L., and Pan, Z.. Elevated orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma. Oncotarget. 5: 3455-71, 2014.
Sakamori, R. Yu, S., Zhang,, X., Hoffman, A., Sun, J., Das, S., Vedula, P., Li, G., Fu, J., Walker, F., Yang, C. S., Yi, Z., Hsu, W., Yu, D-H., Shen, L., Rodriguez, A. J., Taketo, M. M., Bonder, E. M., Verzi, M. P., and Gao, N. CDC42 Inhibition suppresses progression of incipient intestinal tumors. (Online published), Cancer Res. 74: 5480-92, 2014.
Das, G.S., So, J.Y., Wall, B., Wahler, J., Smolarek, A.K., Sae-Tan, S., Soewono, K.Y., Yu, H., Lee, M.J., Thomas, P.E., Yang, C.S., Suh, N. Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats. Mol. Carcinog. (Online published), 2014.
Jin, H., Chen, J.X., Wang, H., Lu, G., Liu, A., Li, G.X., Tu, S., Lin, Y., and Yang, C.S. NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (−)-epigallocatechin-3-gallate. Nutr. & Cancer, 67, 167-76, 2014.
Yang, C.S., and Feng, Q. Chemo/Dietary Prevention of Cancer: Perspectives in China. J. Biomedical Res. 28, 447-55, 2014.
Oh, S., Gwak, J., Park, S., and Yang, C.S. Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation. Biofactors, 40, 586-95, 2014.
Wang, H., Zhou, H., Liu, A., Guo, X., and Yang, C.S. Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of β-catenin/Ctnnb1 as the driver gene for the carcinogenesis. (Online published), Mol. Carcionog. 2014.
Wang, D., Wang, Y., Wan, X., Yang, C.S., and Zhang, J. (2015) Green tea polyphenol (-)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: Responses of major antioxidant enzymes and the Nrf2 rescue pathway. Toxicol Appl Pharmacol, 283, 65-74, 2015.
Awards and Honors
1980 Research Scholar of the U.S. National Academy of Sciences to conduct research in China
1987 to 1995 Merit Award from the National Cancer Institute
1990 Distinguished Researcher Award, NJ Association for Biomedical Research
1991 Board of Trustees Award for Excellence in Research at Rutgers University
1998 Welcome Visiting Professorship (to Penn State University)
2007 Awarded John L. Colaizzi Chair in Pharmacy
2010 Elected as AAAS Fellow of the American Association for the Advancement of Science.