Ernest Mario School of Pharmacy

FACULTY PROFILE


Chung S. Yang, PhD
John L. Colaizzi Endowed Chair in Pharmacy
and Chair, Department of Chemical Biology

Phone: (732) 445 3400 x244
Fax: (732) 445 0687
Email: csyang@rci.rutgers.edu

PhD, Cornell University

 

Bio
 
BS, National Taiwan University, Taipei, Taiwan
PhD, Cornell University, Ithaca, NY
Post-Doc, Scripps Clinic & Research Foundation, La Jolla, CA
 
Research
 
Mechanisms of carcinogenesis and its prevention, including studies on the inhibition of carcinogenesis by tea and its constituents, tocopherols, their combination with commonly used drugs. Research is being conducted in animal models, molecular investigation with cell lines, pharmacokinetics and bioavailability studies in animals and humans, and human intervention studies.

Representative Publications

Hao, J., Zhang, B., Liu, B., Lee, M., Hao, X., Reuhl, K. R., Chen, X., and Yang, C. S. Effect of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal adenocarcinoma formation in a rat surgical model. Int J Cancer, 124: 1270-1275, 2009.

Lu, G., Xiao, H., You, H., Lin, Y., Jin, H., Snagaski, B., and Yang, C.S.  Synergistic Inhibition of Lung Tumorigenesis by a Combination of Green Tea Polyphenols and Atorvastatin.  Clin. Cancer Res. 14: 4981-4988, 2008.

Xiao, H., Hao, X., Simi, B., Ju, J., Jiang, H., Reddy, B.S., and Yang, C.S.  Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats.  Carcinogenesis 29: 113-119, 2008.

Lambert, J.D., Kwon, S. J., Ju, J., Bose, M., Lee, M.J., Hong, J., Hao, X., and Yang, C.S. Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (-)-epigallocatechin-3-gallate. Carcinogenesis, 29: 2019-2024, 2008.

Bose, M., Lambert, J.D., Ju, J., Reuhl, K.R., Shapses, S. A., and Yang, C.S. The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. J Nutr, 138: 1677-1683, 2008.

Awards and Honors

1980    Research Scholar of the U.S. National Academy of Sciences to conduct research in China

1987 - 1995    MERIT Award from the National Cancer Institute

1990    Distinguished Researcher Award, NJ Association for Biomedical Research

1991    Board of Trustees Award for Excellence in Research at Rutgers University

1998    Welcome Visiting Professorship (to Penn State University)

2007    Awarded John L. Colaizzi Chair in Pharmacy