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FACULTY PROFILE


Nanjoo Suh, PhD
Professor
Department of Chemical Biology

Phone: (848) 445 8030
Fax: (732) 445 0687
Email: nsuh@pharmacy.rutgers.edu

PhD, University of Illinois at Chicago

Bio
 
BS, Ewha Women’s University, Seoul, Korea
MS, Seoul National University, Seoul, Korea
PhD, University of Illinois at Chicago, Chicago, IL
 
Research
 
  1. Cancer prevention studies with natural and synthetic agents such as triterpenoids, vitamin D and vitamin E family, stilbenoids and other chemopreventive agents in cancer cell lines as well as in animal models of breast cancer and colon cancer
  2. Investigation of novel Gemini vitamin D analogs in the regulation of Notch signaling in breast cancer stem cells
  3. Investigation of mechanisms of action of dietary tocopherols in animal models of breast cancer
  4. Combination treatment of statins and NSAIDs in the inhibition of colon cancer development in animal models
  5. Molecular mechanism studies targeting TGF-beta/Smad, inducible nitric oxide synthase (iNOS), inducible cyclooxygenase (COX-2), and NF-kB in carcinogenesis
  6. Mechanism studies of anti-inflammatory and chondrogenic action of chemopreventive agents using in vitro, organ culture and in vivo models of osteoarthritis

Representative Publications

Lee, H.J., Ju, J., Paul, S., So, J.Y., DeCastro, A., Smolarek, A.K., Lee, M.-J., Yang, C.S., Newmark, H.L., and Suh, N. Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma. Clin. Can. Res., 15:4242-4249, 2009.

Maehr, H., Lee, H.J., Perry, B., Suh, N., and Uskokovic, M. Calcitriol derivatives with two different side chains at C-20. V. Potent Inhibitors of Mammary Carcinogenesis and Inducers of Leukemia Differentiation. J. Med. Chem. 52:5505-5519, 2009.

Lee, H.J., So, J.Y., DeCastro, A., Smolarek, A., Paul, S., Maehr, H., Uskokovic, M., and Suh, N.  Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling. J. Steroid Biochem. Mol. Biol. 121:408-412, 2010.

Paul, S., DeCastro, A., Lee, H.J., Smolarek, A.K., So, J.Y., Simi, B., Wang, C.X., Zhou, R., Rimando, A.M., and Suh, N.  Dietary intake of pterostilbene, a constituent of blueberries, inhibits the b -catenin/p65 downstream signaling pathway and colon carcinogenesis in rats.  Carcinogenesis. 31:1272-1278, 2010.

So, J.Y., Lee, H.J., Smolarek, A.K., Paul, S., Wang, C.X., Maehr, H., Uskokovic, M., Zheng, X., Conney, A.H., Cai, L., Liu, F., and Suh, N., A novel Gemini vitamin D represses the expression of a stem cell marker CD44 in breast cancer, Mol. Pharmacol., 79: 360-367, 2011.

Huet, T., Maehr, H., Lee, H.J., Uskokovic, M., Suh, N., Moras, D., Rochel, N., Structure-function study of Gemini derivatives with two different side chains at C-20, Gemini-0072 and -0097, Med. Chem. Comm., 2: 424-429, 2011.

Suh, N., Reddy, B.S., DeCastro, A., Paul, S., Lee, H.J., Smolarek, A.K., So, J.Y., Simi, B., Wang, C.X., Janakiram, N.B., Steele, V. and Rao, C.V., Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/-catenin/cyclin D1 signaling pathway in rats, Cancer Prev. Res., 4: 1895-1902, 2011.

Smolarek, A.K., and Suh, N., Chemopreventive activity of vitamin E in breast cancer: A focus on gamma-and delta-tocopherol, Nutrients, 3: 962-986, 2011.

Suh, N., Paul, S., Lee, H.J., Yoon, T., Shah, N., Son, A.I., Reddi, A. H., Medici, D.D., Sporn, M.B., Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis in calvarial organ cultures, Osteoarthritis Cartilage, 20: 446-450, 2012.

Yang C.S., Suh, N., and Kong, A.-N.T., Does vitamin E prevent or promote cancer?, Cancer Prev. Res., 5: 701-5, 2012.

Huang, Y., Khor, T.O., Shu, L., Saw, C.L.-L., Wu, T.Y., Suh, N., Yang, C.S., and Kong, A.-N.T., A g-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation, J. Nutr. 142: 818-23, 2012.

Smolarek, A.K., So, J.Y., Burgess, B., Kong. A.-N.T., Reuhl, K., Lin, Y., Shih, W., Lin, Y., Li, G., Lee, M.J., Chen, Y.-K., Yang, C.S., and Suh, N., Dietary administration of d- and g-tocopherol inhibits tumorigenesis in the animal model of estrogen-receptor positive, but not HER-2 breast cancer, Cancer Prev. Res., 5: 1310-1320, 2012.

Yang, C.S., and Suh, N., Cancer prevention by different forms of tocopherols, Top. Curr. Chem., 329: 21-33, 2013.

So, J.Y., Smolarek, A. K., Salerno, D. M., Maehr, H., Uskokovic, M., Liu, F., and Suh, N., Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer, PLoS One, 8: e54020, 2013.

Su, Z.Y., Khor, T.O., Shu, L., Lee, J.H., Saw, C. L.-L., Wu, T.-Y., Huang, Y., Suh, N., Yang, C.S., Conney, A.H., Wu, Q., and Kong, A.-N. T., Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix Angelica Sinensis via promoter CpG demethylation, Chem. Res. Tox., 26: 477-485, 2013.

Smolarek, A.K., So, J.Y., Thomas, P.E., Lee, H.J., Paul, S., Dombrowski, A., Wang, C.X., Saw, C. L-L., Khor, T.O., Kong, A.N.T., Reuhl, K., Lee, M.J., Yang, C.S., and Suh, N., Dietary tocopherols inhibit cell proliferation, regulate expression of ERa, PPARg, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia, Molecular Carcinogenesis, 52: 514-525, 2013.

Maehr, H., Rochel, N., Lee, H.J., Suh, N., and Uskokovic, M., Diastereotopic and Deuterium Effects in Gemini, J. Med. Chem., 56: 3878-3888, 2013.

So, J.Y., Wahler, J., Yoon, T., Smolarek, A. K., Lin, Y., Shih, W.J., Maehr, H., Uskokovic, M., Liby, K., T., Sporn, M.B., and Suh, N., Oral administration of a Gemini vitamin D analog, a triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression, Cancer Prev. Res., 6: 959-970, 2013.

Wahler, J., So, J.Y., Kim, Y.C., Liu, F., Maehr, H., Uskokovic, M., and Suh, N., Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog. Cancer Prev. Res., 7: 617-626, 2014.

So, J.Y., Lin, J.J., Wahler, J., Liby, K.T., Sporn, M. B., and Suh, N., A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer, PLoS One, 9:e107616, 2014.

Awards and Honors

Member of The Rho Chi Pharmacy Honor Society

AACR Young Investigator Award

Career Development Award, NIH/NCI K22

The Board of Trustees Fellowship for Scholarly Excellence, Rutgers