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FACULTY PROFILE


Suzie Chen, PhD
Professor
Department of Chemical Biology

Phone: (848) 445 7243
Fax: (732) 445 0687
Email: suziec@pharmacy.rutgers.edu

PhD, Albert Einstein College of Medicine

Bio

BS, Trinity College, Hartford, CT
MS, Albert Einstein College of Medicine, Bronx, NY
PhD, Albert Einstein College of Medicine, Bronx, NY
Post-Doc, Columbia University, New York, NY

Research

Molecular mechanisms of melanoma development using a transgenic mouse model system. Involvement of Grm1, a G-protein-coupled receptor in control of cell growth and cell differentiation.

Representative Publications

Pollock, P.M., Cohen-Solal, K.A., Sood, R., Namkoong, J., Martino, J.J., Koganti, A., Zhu, H., Robbins, C., Makalowska, I., Shin, S.S., Marin, Y., Roberts, K.G., Yudt, L.M., Chen, A., Cheng, J., Incao, A., Pinkett, H.W., Graham, C.L., Dunn, K., Crespo-Carbone, S.M., Mackason, K.R., Ryan, K.B., Sinsimer, D., Goydos, J., Reuhl, K.R., Eckhaus, M., Meltzer, P.S., Pavan, W.J., Trent, J.M. and Chen, S. (2003) Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet. 38:108-112. PMID 12704387

Yip, D., Le, M., Chan, J., Lee, J., Mehnert, J., Yudd, A., Kempf, J., Shih, W., Chen, S. and Goydos, J.   (2009) A phase 0 trial of Riluzole in patients with resectable stage III and IV melanoma. Clin. Can. Res. 15: 3896-3902. PMCID: PMC2812866

Lee, H. J., Wall, B., Wangari-Talbot, J., Shin, S. S., Rosenberg, S., Chan, J. L. K., Namkoong, J., Goydos, J. and Chen, S. (2011) Glutamatergic pathway targeting in melanoma; single agent and combinatorial therapies. Clin Can Res. 17:7080-7092. PMID: 21844014 PMCID: PMC3218300

Wangari-Talbot, J., Wall, B. A., Goydos, J. S. and Chen, S. (2012) Functional effects of GRM1 suppression in human melanoma cells. Mol. Can. Res. 10: 1-11. PMID: 22798429 PMCID: PMC3501593

Wall, B., Wangari-Talbot, J., Shin, S., Schiff, D., Sierra, J., Yu, L. J., Khan, A., Haffty, B., Goydos, J. and Chen, S. (2013) Disruption of GRM1-mediated signaling using riluzole results I DNA damage in melanoma cells. Pigment Cell Melanoma Res. 27(2):263-74.

Teh, J., Shah, R., Shin, S. S., Wen, Y., Mehnert, J., Goydos, J. and Chen, S . Metabotropic glutamate receptor 1 (mGluR1) mediates melanocyte transformation via transactivation of insulin-like growth factor 1 Receptor. Pigment Cell Melanoma Res. 27: 621-629, 2014.

Wall, B., Khan, A., Goydos, J., Haffty, B. and Chen, S . Riluzole is a radio-sensitizing agent in an in vivo model of brain metastasis derived from GRM1 expressing human melanoma cells. Pigment Cell Melanoma Res . Epub ahead of print. 2014. doi: 10.1111/pcmr.12327.