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Faculty Profile

 

       
Leonid Kagan, Ph.D.
Assistant Professor 
Department of Pharmaceutics
William Levine Hall, Room 220 

Phone: 848-445-6365
Fax: 732-445-3134

Email: lkagan@pharmacy.rutgers .edu   

           

 Research Interests

  • Pain and Analgesia
    • Mechanisms of pain
    • Analgesic drugs
    • Chemotherapy-induced neuropathic pain

  • Pharmacokinetic (PK) and pharmacodynamic (PD) of protein
    therapeutics (monoclonal antibodies, cytokines)
    • Mechanisms of subcutaneous absorption, lymphatic absorption

  • PKPD modeling and simulation
    • Pharmacometrics and population modeling
    • Physiologically-based (PBPK) and mechanism-based models
    • Disease progression modeling
    • Interspecies modeling and human predictions
  • PK and PD in special patient populations
    • Obesity
  • Effect of formulations on PK and PD

Education

2004-2008    Ph.D. inPharmaceutics, The Hebrew University of Jerusalem
2008-2010    Pos-Doctoral Fellow, Center for Protein Therapeutics, Department
                     of Pharmaceutical Sciences, University at Buffalo, SUNY

Selected Publications

Passey C, Kimko H, Nandy P, and Kagan L (2015) Osteoarthritis disease progression model using six year follow-up data from the osteoarthritis initiative. J Clin Pharmacol 55:269-278

Kagan L (2014) Pharmacokinetic modeling of the subcutaneous absorption of therapeutic proteins. Drug Metab Dispos 42:1890-1905.

Kagan L, Zhao J, and Mager DE (2014) Interspecies pharmacokinetic modeling of subcutaneous absorption of rituximab in mice and rats. Pharm Res 31:3265-3273.

Kagan L, Gershkovich P, Wasan KM, and Mager DE (2014) Dual physiologically based pharmacokinetic model of liposomal and nonliposomal amphotericin B disposition. Pharm Res 31:35-45.

Haroutiunian S, Kagan L, Yifrach-Damari I, Davidson E, Ratz Y, and Hoffman A (2014) Enhanced antinociceptive efficacy of epidural compared with i.v. methadone in a rat model of thermal nociception. Br J Anaesth 112:150-158.

Chen T, Mager DE, and Kagan L (2013) Interspecies modeling and prediction of human exenatide pharmacokinetics. Pharm Res 30:751-760.

Kagan L, Turner MR, Balu-Iyer SV, and Mager DE (2012) Subcutaneous absorption of monoclonal antibodies: role of dose, site of injection, and injection volume on rituximab pharmacokinetics in rats. Pharm Res 29:490-499.

Kagan L, Gershkovich P, Wasan KM, and Mager DE (2011) Physiologically based pharmacokinetic model of amphotericin B disposition in rats following administration of deoxycholate formulation (Fungizone(R)): pooled analysis of published data. AAPS J 13:255-264.

For a complete list of publications on Pubmed, please click here.

Teaching

Introduction to Biopharmaceutics and Pharmacokinetics (30:721:430)
Advanced Pharmacokinetics/Dynamics (16:720:509)
Molecular and Cellular Pharmaceutics (16:720:614)
Biochemical Toxicology (16:963:505)

Membership in Professional Organizations

The Cancer Institute of New Jersey (CINJ)
International Society of Pharmacometrics (ISOP)
American Society for Pharmacology and Experimental Therapeutics (ASPET)
American Pain Society (APS)
International Association for the Study of Pain (IASP)
American Association of Pharmaceutical Sciences (AAPS)