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FACULTY PROFILE

 


S. David Kimball, PhD
Research Professor
Department of Medicinal Chemistry

Phone: (848) 445 6493
Fax: (732) 445 6312
Email: dkimball@pharmacy.rutgers.edu

Ph.D. SUNY at Stony Brook

 

Bio

SUNY at Stony Brook, 1978, B.A. Experimental Psychology
SUNY at Stony Brook, 1982, Ph.D. Organic Chemistry/Chemical Biology
Bristol-Myers Squibb, 1982-2001, Research Fellow, Medicinal Chemistry
Lexicon Pharmaceuticals 2001-2007, Vice President, Medicinal Chemistry
Pharmacopeia, 2007-2008, Senior Vice President, Drug Discovery & Nonclinical Development
Hydra Biosciences, 2008-2011, Chief Scientific Officer
Associate Member of Graduate Faculty, Rutgers University, 1989-2011

Research

My research career has focused on the discovery of novel small molecule treatments for human disease, spanning several therapeutic areas.  This work includes cardiovascular disease, metabolic disease, inflammation, oncology, neuroscience and pain.  In each program, the appropriate drug discovery tools have been applied to solving scientific problems, including structure-based design, parallel synthesis, high throughput and phenotypic screening, and the evaluation of knockout mouse phenotypes to identify novel drug targets.

Our immediate research interests include the role of ApoE in Alzheimer’s disease, traumatic brain injury and the structure-based design of kinase inhibitors for cancer and inflammatory disease.

Representative Publications

Dong, H. Zhang, L. Boteju, J. Hazelwood, J. Yan, M. Bednarz, S. Layek, I.B. Owusu, S. Gopinathan, L. Moran, Z. Lai, J. Kramer, S.D. Kimball, P. Yalamanchili, W.E. Heydorn, K.S. Frazier, B. Brooks, P. Brown, A. Wilson, W.K. Sonnenburg, A. Main, K.G. Carson, T. Oravecz, D. J. Augeri.  Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid J.T. Bagdanoff, M.S. Donoviel, A. Nouraldeen, M. Carlsen, T.C. Jessop, J. Tarver, S. Aleem, L. Arthritis: Discovery of (E)-1-(4-(1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazoly-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).  J. Med. Chem. 2010 (53) 8650-8662.

R. Bakthavatchalam and S. D. Kimball.  Modulators of TRP Ion Channels.  Annual Reports in Medicinal Chemistry 2010 (45) 37-50.

T.C. Jessop, J.E. Tarver, M. Carlsen, A. Xu, J.P. Healy, A. Heim-Riether, Q. Fu, J.A. Taylor, D.J. Augeri, M. Shen, T.R. Stouch, R.V. Swanson, L.W. Tari, M. Hunter, I. Hoffman, P.E. Keyes, X-C. Yu, M. Miranda, Q. Liu, J.C. Swaffield, S.D. Kimball, A. Nouraldeen, A.G.E. Wilson, A. M. DiGeroge Foushee, K. Jhaver, R. Finch, S. Anderson, T. Oravecz, K.G. Carson.  Lead Optimization and Structure-based Design of Potent and Bioavailable Deoxycytidine Kinase Inhibitors.  Bioorg. Med. Chem. Lett. 2009 (19) 6784-6787.

J.E. Tarver, T.C. Jessop, M. Carlsen, D.J. Augeri, Q. Fu, J.P. Healy, A. Heim-Riether, A. Xu,  J.A. Taylor, M. Shen, P.E. Keyes, S.D. Kimball, X-C. Yu, M. Miranda, Q. Liu, J.C. Swaffield, A. Nouraldeen, A.G.E. Wilson, R. Finch, K. Jhaver, A. M. DiGeroge Foushee, S. Anderson, T. Oravecz, K.G. Carson.  5-Fluorocytosine Derivatives as Inhibitors of Deoxycytidine Kinase.  Bioorg. Med. Chem. Lett. 2009 (19) 6780-6783.

J.T. Bagdanoff, M.S. Donoviel, A. Nouraldeen, J. Tarver, Q. Fu, M. Carlsen, T. Jessop, H. Zhang, J. Hazelwood, H. Nguyen, S.D.P. Baugh, M. Gardyan, K.M. Terranova, J. Barbosa, J. Yan, M. Bednarz, S. Layek, J. Taylor, A.M. Digeroge-Foushee, S. Gopanithan, D. Bruce, T. Smith, L. Moran, E. O’Neill, J. Kramer, Z. Lai, S.D. Kimball, Q. Liu, W. Sun, S. Yu, J. Swaffield, A. Wilson, A. Main, K.G. Carson, T. Oravecz, D.J. Augeri. Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders.  J. Med. Chem. 2009 (52) 3941-3953.

N.C. Goodwin, R. Mabon, B.A. Harrison, M.K. Shadoan, Z.Y. Almstead, Y. Xie, J. Healy, L.M. Buhring, C.M. DaCosta, J. Bardenhagen, F. Mseeh, Q. Liu, A. Nouraldeen, A.G.E. Wilson, S.D. Kimball, D.R. Powell, D.B. Rawlins.  Novel L-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes.  J. Med. Chem. 2009 (52) 6201-6204.

B.A. Harrison, N.A. Whitlock, M.V. Voronkov, Z.Y. Almstead, K.J. Gu, R. Mabon, M. Gardyan, B.D. Hamman, J. Allen, S. Gopinathan, B. McKnight, M. Crist, Y. Zhang, Y. Liu, J. Zhou, N. Paten, Q. Liu, A.G.E. Wilson, S.D. Kimball, D.S. Rice, D.B. Rawlins.  A Novel Class of LIM-kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma.  J. Med. Chem 2009 (52) 6515-6518.

Z.-C. Shi, A. Devasagayaraj, K. Gu, H Jin, B. Marinelli, L. Samala, S. Scott, T. Stouch, A. Tunoori, Y. Wang, Y. Zang, C. Zhang, S.D. Kimball, A.J. Main, W. Sun, Q. Yang, A. Nouraldeen,  X.-Q. Yu,  E. Buxton, S. Patel, N. Nguyen, J. Swaffield, D.R. Powell, A. Wilson, Q. Liu.  Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders.  J. Med. Chem. 2008 (51) 3684-3687.
B.E. Fink, A.V. Gavai, J.S. Tokarski, B. Goyal, R. Misra, H-Y. Xiao, S.D. Kimball, W-C. Han, D. Norris, T.E. Spires, D. You, M.M. Gottardis, M.V. Lorenzi, G.D. Vite.  Identification of a Novel Series of Tetrahydrodibenzazocines as Inhibitors of 17 b-hydroxysteroid dehydrogenase type 3.  Bioorg. Med. Chem. Lett. 2006 (16) 1532-1536.

R.N. Misra, H.Y. Xiao, K.S. Kim, S. Lu, W.C. Han, S.A. Barbosa, J.T. Hunt, D.B. Rawlins, W. Shan, S.Z. Ahmed, L. Qian, B.C. Chen, R. Zhao, M.S. Bednarz, K.A. Kellar, J.G. Mulheron, R. Batorsky, U. Roongta, A. Kamath, P. Marathe, S. A. Ranadive, J. S. Sack, J.S. Tokarski, N.P. Pavletich, F.Y.F. Lee, K.R. Webster, S.D. Kimball.  N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2.  N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent.  J. Med. Chem. 2004 (47) 1719-1728.