Pharmacy Website



Arash Hatefi , Ph.D.
Associate Professor
Department of Pharmaceutics
William Levine Hall, Rm 222
160 Frelinghuysen Road, Piscataway, NJ, 08854
Phone: 848-445-6366
Fax: 848-445-6366

Open Positions
Postdoctoral Fellowship: Closed
PhD student: One postion available. The student must be able to show financial support for the first year of his/her PhD Studies (self-funded). Financial support for subsequent years of the PhD study will be provided by the Department through Teaching Assistantships. For initial evaluation, please email your CV to:
Masters student: One position is available. The student must be able to show financial support for the duration of his/her studies (self-funded).
For initial evaluation, please email your CV to:
Research interests
• Design and development of non-viral vectors (nanomedicine) for image-guided cancer gene therapy.
• Stem cell engineering for imaging and therapy of cancer
• Cancer Immunotherapy
•  Recombinant production of difficult-to-make peptides/proteins
1998 – 2002   Ph.D. in Pharmaceutical Sciences
                       University of Alberta, Canada
2003 – 2006   Postdoctoral Fellow (Recombinant Vector Engineering, Cancer Gene Therapy)
                       University of Maryland, Baltimore, USA
2015-2020     NIH/NCI (R01CA175318)
2014-2016     NIH/NIBIB (R21EB016792)
2012-2013     Rutgers University Faculty Research Grant (#281663)
2010-2015     American Society for Pharmacology and Experimental Therapeutics (SURF Program)
2009-2013     Department of Defense Prostate Cancer Program New Investigator Award (PC081055)
2007-2008     Department of Defense Breast Cancer Program Concept Award (BC062929)
2006-2007     American Cancer Society Institutional Research Grant (IRG-77-003-26)
Journal Editorial Activity
Since 2016    Associate Editor, Journal of "Nanomedicine: Nanotechnology, Biology and Medicine"
Since 2013    Editorial board member, Journal of "Pharmaceutics & Pharmacology"
2011            Theme Editor of “Advances in Image-Guided Drug Delivery”
                    Journal: Drug Delivery and Translational Research
2010            Theme Editor of “Advances in Recombinant Polymers for Delivery of Bioactive Agents”
                    Journal: Advanced Drug Delivery Reviews
Since 2008   Associate Editor, Journal of "Bioactive and Compatible Polymers"

Peer Reviewed Journal Publications
For complete list of publications on Pubmed, please click here or see below:
36. F.S. Nouri, D. Banerjee, A. Hatefi, Practical Issues with the Use of Stem Cells for Cancer Gene Therapy. Stem Cell Rev 11 (5): 688-98 (2015) 
35. Z. Karjoo, X. Chen, A. Hatefi, Progress and Problems with the Use of Suicide Genes for Targeted Cancer Therapy. Adv Drug Deliv Rev (2015) In press
34.    F.S. Nouri, X. Wang, X. Chen, A. Hatefi, Reducing the Visibility of the Vector/DNA Nanocomplexes to the Immune System by Elastin-Like Peptides. Pharm Res 32(9):3018-28 (2015).
33.    F.S. Nouri, X. Wang, A. Hatefi, Genetically engineered theranostic mesenchymal stem cells for the evaluation of the anticancer efficacy of enzyme/prodrug systems. J Control Release 200:179-187 (2015)
32.     B.A. Khaw, K.S. Gada, V. Patil, R. Panwar, S. Mandapati, A. Hatefi, S. Majewski, A. Weisenberger A. Bispecific antibody complex pre-targeting and targeted delivery of polymer drug conjugates for imaging and therapy in dual human mammary cancer xenografts : Targeted polymer drug conjugates for cancer diagnosis and therapy. Eur J Nucl Med Mol Imaging 41(8):1603-16 (2014)
31.     Y. Wang, L. Zhang, S. Guo, A. Hatefi, L. Huang, Incorporation of histone derived recombinant protein for enhanced disassembly of core-membrane structured liposomal nanoparticles for efficient siRNA delivery. J Control Release 172(1):179-189 (2013)
30.     F.S. Nouri, X. Wang, M. Dorrani, Z. Karjoo, A. Hatefi, A Recombinant Biopolymeric Platform for Reliable Evaluation of the Activity of pH-Responsive Amphiphile Fusogenic Peptides. Biomacromolecules 14:2033-2040 (2013)
29.      H. Parhiz, M. Hashemi, A. Hatefi, W.T. Shier, S.A. Farzad, M. Ramezani, Arginine-Rich Hydrophobic Polyethylenimine; Potent Agent with Simple Components for Nucleic Acid Delivery. Int J Biol Macromol 60:18-27 (2013)
28.      Z. Karjoo, H.O. McCarthy, P. Patel, F.S. Nouri, A. Hatefi, Systematic Engineering of Uniform and Highly Efficient Targeted-Shielded Viral-Mimetic Nanoparticles. Small 9(16):2774-83 (2013)
27.     T. Minko, A. Hatefi, Preface-tenth international nanomedicine and drug delivery symposium (NanoDDS'12). J Control Release 171(3):259-60 (2013) 
26.     F. Soltani, M. Sankian, A. Hatefi, M. Ramezani, Development of a novel histone H1-based recombinant fusion peptide for targeted non-viral gene delivery. Int J Pharm 441(1-2):307-15 (2013)
25.     H. Parhiz, M. Hashemi, A. Hatefi , W.T. Shier, S.A.Farzad, M. Ramezani, Molecular weight-dependent genetic information transfer with disulfide-linked polyethylenimine-based nonviral vectors. J Biomater Appl (1):112-24 (2013)
24.    F. Sadeghian, S. Hosseinkhani, A. Alizadeh, A. Hatefi, Design, engineering and preparation of a multi-domain fusion vector for gene delivery. Int J Pharm 427(2):393-9 (2012)

23.    K. S. Gada, V. Patil, R. Panwar, A. Hatefi, and B. Khaw. Bispecific Antibody Complex Pre-targeted Delivery of Polymer–Drug Conjugates for  Cancer Therapy. Drug Deliv and Transl Res 2:65–76 (2012)
22.    B. F. Canine, Y. Wang, W. Ouyang, and A. Hatefi. Development of Targeted Recombinant Polymers that can deliver siRNA to the Cytoplasm and Plasmid DNA to the Cell Nucleus. J Control Release 405(1-2):196-202 (2011)

21.    H.O. McCarthy, A.V. Zholobenko, Y. Wang, B. Canine, T. Robson, D.G. Hirst, A. Hatefi. Evaluation of a Multi-Functional Nanocarrier for Targeted Breast Cancer iNOS Gene Therapy. Int J Pharm 405(1-2):196-202 (2011)

20.    M. Hashemi, B.H. Parhiz, A. Hatefi, M. Ramezani. Modified polyethyleneimine with histidine-lysine short peptides as gene carrier. Cancer Gene Therapy 1:12-19 (2011)

19.    Y. Wang, B.F. Canine, A. Hatefi, HSV-TK/GCV Cancer Suicide Gene Therapy by a Designed Recombinant Multifunctional Vector. Nanomedicine 7 (2):193-200 (2011)
18.    H. Ghandehari, A. Hatefi, Advances in recombinant polymers for delivery of bioactive agents. Adv Drug Delivery Rev, 62 (15):1403 (2010)

17.    B.F. Canine, A. Hatefi, Development of cationic recombinant polymers for gene therapy research, Adv Drug Delivery Rev, 62 (15):1524-9 (2010)

16.    H.O. McCarthy, Y. Wang, S.S. Mangipudi, and A. Hatefi, Advances with the use of bio-inspired vectors towards creation of artificial viruses. Expert Opin Drug Deliv 7 (4) (2010) 1-16.

15.     B.F. Canine, Y. Wang, A. Hatefi, Biosynthesis and characterization of a novel genetically engineered polymer for targeted gene transfer to cancer cells. J Control Release 138 (3) (2009) 188-196.   
14.    S.S. Mangipudi, B.F. Canine, Y. Wang, A. Hatefi, Development of a genetically engineered biomimetic vector for targeted gene transfer to breast cancer cells. Mol Pharm 6 (4) (2009) 1100–1109.

13.     A. Hatefi and B. Canine, Perspectives in vector development for systemic cancer gene therapy. Gene Ther Mol Biol 13 (2009) 15-19.

12.    Y. Wang, S.S. Mangipudi, B.F. Canine, A. Hatefi, A designer biomimetic vector with a chimeric architecture for targeted gene transfer. J Control Release 137 (2009) 46-53.   

11.     A. Dehshahri, R.K. Oskuee, W.T. Shier, A. Hatefi, and M. Ramezani, Gene transfer efficiency of high primary amine content, hydrophobic, alkyl-oligoamine derivatives of polyethylenimine. Biomaterials 30 (25) (2009) 4187-94.

10.     A. Hatefi and H. Ghandehari, Recombinant Polymers: Promise for Gene Therapy. Controlled Release Society Newsletter 26 (2) (2009)16-18.

9.     B.F. Canine, Y. Wang, A. Hatefi, Evaluation of the effect of vector architecture on DNA condensation and gene transfer efficiency. J Control Release 129 (2008) 117-123.

8.    A. Hatefi, J. Cappello, H. Ghandehari, Adenoviral gene delivery to solid tumors by recombinant silk-elastinlike protein polymers. Pharm Res 24(4) (2007) 773-779.

7.    A. Hatefi, Z. Megeed, H. Ghandehari, Recombinant polymer-protein fusion: a promising approach towards efficient and targeted gene delivery. J Gene Med 8(4) (2006) 468-476.

6.    M. Haider, A. Hatefi, H. Ghandehari, Recombinant polymers for cancer gene therapy: a minireview. J Control Release 109(1-3) (2005) 108-119.

5.    A. Hatefi, D. Knight, B. Amsden, A biodegradable injectable thermoplastic for localized camptothecin delivery. J Pharm Sci 93(5) (2004) 1195-1204.

4.    B. Amsden, A. Hatefi, D. Knight, E. Bravo-Grimaldo, Development of biodegradable injectable thermoplastic oligomers. Biomacromolecules 5(2) (2004) 637-642.

3.    A. Hatefi, B. Amsden, Biodegradable injectable in situ forming drug delivery systems. J Control Release 80(1-3) (2002) 9-28.

2.    A. Hatefi, B. Amsden, Camptothecin delivery methods. Pharm Res 19(10) (2002) 1389-1399.

1.    M.R. Tehrani and A. Hatefi. Characterization and evaluation of enteric-coated controlled release tablet formulations of diclofenac sodium. Acta Pharmaceut (1996) 46: 285-294.

Book Chapter
Karjoo, Z.; Ganapathy, V.; Hatefi, A., Gene Directed Enzyme Prodrug Cancer Therapy. In Gene Therapy of Cancer, Lattime, E. C.; Gerson, S. L., Eds. Elsevier Inc.: 2013, pages 77-91

2007   Z. Megeed, A. Hatefi, H. Ghandehari, Recombinant protein polymer vectors for systemic gene delivery, Publication Number: US 20070098702 A1
2015   A. Hatefi, Low-Immunogenic Elastin Like Oligopeptides And Methods of Use Thereof. Provisional Patent Application Number 5702US02.
Genetically Engineered Drug Delivery Systems (Graduate level course)
Introduction to Pharmaceutics (Pharm.D. level course)
Membership in Professional Organizations
Since 1999       American Association of Pharmaceutical Scientists (AAPS)
Since 2001       Controlled Release Society (CRS)
Since 2002       Canadian Society for Pharmaceutical Scientists (CSPS)
2004-2015       American Society of Gene and Cell Therapy  (ASGCT)
2007-2015       American Society for Pharmacology and Experimental Therapeutics (ASPET)
Since 2007       American Association of Cancer Research  (AACR)